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Fig. 2 | BMC Medical Genomics

Fig. 2

From: Genome-wide association study identifies new loci associated with risk of HBV infection and disease progression

Fig. 2

accessed from 1000 Genome Project. EAS, AFR, SAS, EUR, AMR refer to East Asian, African, South Asian, European and American of 1000 Genome Project, respectively. The racial tree indicated a genetic difference in HBV-infection related genes among EAS, AFR, SAS, EUR, AMR. The genetic difference (Right) of each SNPs was evaluated by FST value. X-axis refer to physical position in chromosome 6. Y-axis refer to FST value of paired SNP. FST values of all paired SNPs of AFR, SAS, AMR, EUR versus EAS were displayed in grey bar. FST values accessed 0.15 (Red horizontal line) indicated the signal of selective event. Red bars and rs IDs showed the reported HBV infection-related SNPs. The FST values of European versus East Asian showed the genetic difference in HLA-DPA1 and HLA-DPB1, indicating a genetic selection against the HBV infection. The racial tree showed that the East Asian population is at the root, indicating that why we used East Asian population as a comparative population but not the other population, and compared other four populations with East Asian population

The racial tree (Left) was based on the SNPs in HBV-infection related genes, including HLA-DRA, HLA-DRB1, HLA-DPA1 and HLA-DPB1. The genotype and minor allele frequency of each SNPs were

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