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Table 2 The significance of HBV-related outcomes study

From: Genome-wide association study identifies new loci associated with risk of HBV infection and disease progression

Case–control studies SNP Gene P value OR Minor Allele Minor Allele Frequency Report λ
Case (n) Control (n) Case Control
Infection (587) Clearance (275) rs2395166 HLA-DRA 1.42 × 10–7 0.4534 C 0.1269 0.2182 MHC region 1.003
rs615672 HLA-DRB1 8.54 × 10–7 0.5697 G 0.405 0.5276 MHC region
rs3077 HLA-DPA1 6.60 × 10–9 0.5007 A 0.2675 0.4145 (Kamatani et al., 2009)
rs9277542 HLA-DPB1 1.53 × 10–8 0.5353 T 0.3735 0.5347 (Kamatani et al., 2009)
CHB (93) ASPI (92) rs1264473 GRHL2 1.57 × 10–6 3.931 C 0.4402 0.1957 Novel 1.052
HCC (214) CHB (93) rs2833856 EVA1C 1.62 × 10–6 0.3515 C 0.2243 0.4086 Novel 1.022
HCC (214) DC (188) rs4661093 ETV3 2.26 × 10–6 2.841 A 0.2104 0.0882 Novel 1.022
  1. Abbreviations: OR, odds ratio; ASPI, asymptomatic persistence infection; CHB, chronic hepatitis B; DC, decompensated cirrhosis; HCC, hepatocellular carcinoma; MHC, major histocompatibility complex; λ: statistics of genomic control