|
Case–control studies
|
SNP
|
Gene
|
P value
|
OR
|
Minor Allele
|
Minor Allele Frequency
|
Report
|
λ
|
|---|
|
Case (n)
|
Control (n)
|
Case
|
Control
|
|---|
|
Infection (587)
|
Clearance (275)
|
rs2395166
|
HLA-DRA
|
1.42 × 10–7
|
0.4534
|
C
|
0.1269
|
0.2182
|
MHC region
|
1.003
|
|
rs615672
|
HLA-DRB1
|
8.54 × 10–7
|
0.5697
|
G
|
0.405
|
0.5276
|
MHC region
|
|
rs3077
|
HLA-DPA1
|
6.60 × 10–9
|
0.5007
|
A
|
0.2675
|
0.4145
|
(Kamatani et al., 2009)
|
|
rs9277542
|
HLA-DPB1
|
1.53 × 10–8
|
0.5353
|
T
|
0.3735
|
0.5347
|
(Kamatani et al., 2009)
|
|
CHB (93)
|
ASPI (92)
|
rs1264473
|
GRHL2
|
1.57 × 10–6
|
3.931
|
C
|
0.4402
|
0.1957
|
Novel
|
1.052
|
|
HCC (214)
|
CHB (93)
|
rs2833856
|
EVA1C
|
1.62 × 10–6
|
0.3515
|
C
|
0.2243
|
0.4086
|
Novel
|
1.022
|
|
HCC (214)
|
DC (188)
|
rs4661093
|
ETV3
|
2.26 × 10–6
|
2.841
|
A
|
0.2104
|
0.0882
|
Novel
|
1.022
|
- Abbreviations: OR, odds ratio; ASPI, asymptomatic persistence infection; CHB, chronic hepatitis B; DC, decompensated cirrhosis; HCC, hepatocellular carcinoma; MHC, major histocompatibility complex; λ: statistics of genomic control
