Genome-wide association study identifies new loci associated with risk of HBV infection and disease progression

BMC Medical Genomics

Table 2 The significance of HBV-related outcomes study

Case–control studies			SNP	Gene	P value	OR	Minor Allele	Minor Allele Frequency		Report	λ
Case (n)	Control (n)		SNP	Gene	P value	OR	Minor Allele	Case	Control	Report	λ
Infection (587)	Clearance (275)		rs2395166	HLA-DRA	1.42 × 10^–7	0.4534	C	0.1269	0.2182	MHC region	1.003
			rs615672	HLA-DRB1	8.54 × 10^–7	0.5697	G	0.405	0.5276	MHC region
			rs3077	HLA-DPA1	6.60 × 10^–9	0.5007	A	0.2675	0.4145	(Kamatani et al., 2009)
			rs9277542	HLA-DPB1	1.53 × 10^–8	0.5353	T	0.3735	0.5347	(Kamatani et al., 2009)
CHB (93)		ASPI (92)	rs1264473	GRHL2	1.57 × 10^–6	3.931	C	0.4402	0.1957	Novel	1.052
HCC (214)	CHB (93)		rs2833856	EVA1C	1.62 × 10^–6	0.3515	C	0.2243	0.4086	Novel	1.022
HCC (214)	DC (188)		rs4661093	ETV3	2.26 × 10^–6	2.841	A	0.2104	0.0882	Novel	1.022

Abbreviations: OR, odds ratio; ASPI, asymptomatic persistence infection; CHB, chronic hepatitis B; DC, decompensated cirrhosis; HCC, hepatocellular carcinoma; MHC, major histocompatibility complex; λ: statistics of genomic control

ISSN: 1755-8794