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Table 3 Divided allele frequency of significant SNPs in MHC region

From: Genome-wide association study identifies new loci associated with risk of HBV infection and disease progression

SNP Study Population Derived Allele Derived Allele Frequency P value
Case–control studies gnomAD East Asian vs non-East Asian
Infection Clearance Healthy East Asian non-East Asian
rs2395166 our study Chinese C 0.127 0.218 0.183 0.128 0.367 4.367 × 10–195
rs615672 our study Chinese G 0.405 0.528 0.512 0.388 0.590 6.003 × 10–111
rs3077 our study Chinese A 0.268 0.415 0.379 0.283 0.723  
Kamatani et al., 2009 [5] Japanese 0.245 - 0.392  
Guo et al., 2011 [55] Chinese 0.314 0.447 0.443 0
Nishida et al., 2012 [56] Japanese, Korean 0.213 0.393 -  
Wong et al., 2013 [57] Southern Chinese 0.206 0.276 0.288  
rs9277341 our study Chinese T 0.142 0.242 0.196 0.159 0.582 0
Guo et al., 2011 [55] Chinese 0.133 0.237 0.237  
rs9277542 our study Chinese T 0.374 0.535 0.482 0.339 0.627 2.005 × 10–225
Kamatani et al., 2009 [5] Japanese 0.246 - 0.437  
  1. Abbreviations: East Asian, East Asian population in gnomAD database; non-East Asian, combined all other population excepted East Asian in gnomAD database; P value, compared allele frequency between East Asian and non-East Asian population via fisher exact test. Derived Allele was accessed from human ancestral genome (Ensembl-59)