Genome-wide association study identifies new loci associated with risk of HBV infection and disease progression

BMC Medical Genomics

Table 3 Divided allele frequency of significant SNPs in MHC region

SNP	Study	Population	Derived Allele	Derived Allele Frequency					P value
				Case–control studies			gnomAD		East Asian vs non-East Asian
				Infection	Clearance	Healthy	East Asian	non-East Asian	East Asian vs non-East Asian
rs2395166	our study	Chinese	C	0.127	0.218	0.183	0.128	0.367	4.367 × 10^–195
rs615672	our study	Chinese	G	0.405	0.528	0.512	0.388	0.590	6.003 × 10^–111
rs3077	our study	Chinese	A	0.268	0.415	0.379	0.283	0.723
	Kamatani et al., 2009 [5]	Japanese		0.245	-	0.392
	Guo et al., 2011 [55]	Chinese		0.314	0.447	0.443			0
	Nishida et al., 2012 [56]	Japanese, Korean		0.213	0.393	-
	Wong et al., 2013 [57]	Southern Chinese		0.206	0.276	0.288
rs9277341	our study	Chinese	T	0.142	0.242	0.196	0.159	0.582	0
rs9277341	Guo et al., 2011 [55]	Chinese	T	0.133	0.237	0.237	0.159	0.582
rs9277542	our study	Chinese	T	0.374	0.535	0.482	0.339	0.627	2.005 × 10^–225
rs9277542	Kamatani et al., 2009 [5]	Japanese	T	0.246	-	0.437	0.339	0.627

Abbreviations: East Asian, East Asian population in gnomAD database; non-East Asian, combined all other population excepted East Asian in gnomAD database; P value, compared allele frequency between East Asian and non-East Asian population via fisher exact test. Derived Allele was accessed from human ancestral genome (Ensembl-59)

ISSN: 1755-8794