Genome-wide association study identifies new loci associated with risk of HBV infection and disease progression

BMC Medical Genomics

Table 4 The significance of progressive HBV infection study

SNP	Gene	P value	Resistant Allele	Resistant Allele Frequency			Related Risk
SNP	Gene	P value	Resistant Allele	CHB	ASPI	Clearance	CHB (vs ASPI)	Clearance (vs ASPI)
rs615672	HLA-DRB1	1.39 × 10^–6	G	0.3297	0.4185	0.5276	0.82	1.12
rs9277542	HLA-DPB1	1.50 × 10^–9	T	0.3011	0.375	0.5347	0.84	1.17
rs3128923	HLA-DPA2	2.06 × 10^–6	G	0.3804	0.4348	0.5636	0.89	1.14
rs1537862	LACE1	1.85 × 10^–6	C	0.6	0.6374	0.7647	0.92	1.19

Abbreviations: ASPI, asymptomatic persistence infection; CHB, chronic hepatitis B. RR was calculated with the comparison of CHB and ASPI, Clearance and ASPI respectively

ISSN: 1755-8794