Airway gene-expression classifiers for respiratory syncytial virus (RSV) disease severity in infants

BMC Medical Genomics

Table 2 Performance of four models used in developing NGSS1 and NGSS2

	Number of genes selected	Naïve RSS	Naïve correlation	Naïve misclassified subjects (out of 106)	CV RSS	CV Correlation	CV prediction accuracy	CV misclassified subjects (out of 106)
Model 1	39 genes	1.234	0.909	15	2.743	0.797	77.4%	24
Model 2^*	41genes	0.884	0.935	9	2.681	0.813	89.6%	11
Model 3	42 genes	0.920	0.933	13	2.119	0.844	78.3%	23
Model 4^**	13 genes	2.549	0.800	16	3.215	0.741	84.0%	17

Naïve and CV RSS are the mean residual sums of squares of the predictive model in the original and cross-validation analyses, respectively. Correlation are the Pearson correlation coefficient between the predicted severity scores and the clinically defined GRSS. Prediction accuracy is the percentage of correctly predicted mild (NGSS ≤ 3.5) or severe (NGSS > 3.5) symptoms, compared with the same phenotype defined by the GRSS (mild: GRSS ≤ 3.5; severe: GRSS > 3.5)
*Designated NGSS1. **Designated NGSS2

ISSN: 1755-8794