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Table 2 Performance of four models used in developing NGSS1 and NGSS2

From: Airway gene-expression classifiers for respiratory syncytial virus (RSV) disease severity in infants

  Number of genes selected Naïve RSS Naïve correlation Naïve misclassified subjects
(out of 106)
CV RSS CV Correlation CV prediction accuracy CV misclassified subjects
(out of 106)
Model 1 39 genes 1.234 0.909 15 2.743 0.797 77.4% 24
Model 2* 41genes 0.884 0.935 9 2.681 0.813 89.6% 11
Model 3 42 genes 0.920 0.933 13 2.119 0.844 78.3% 23
Model 4** 13 genes 2.549 0.800 16 3.215 0.741 84.0% 17
  1. Naïve and CV RSS are the mean residual sums of squares of the predictive model in the original and cross-validation analyses, respectively. Correlation are the Pearson correlation coefficient between the predicted severity scores and the clinically defined GRSS. Prediction accuracy is the percentage of correctly predicted mild (NGSS ≤ 3.5) or severe (NGSS > 3.5) symptoms, compared with the same phenotype defined by the GRSS (mild: GRSS ≤ 3.5; severe: GRSS > 3.5)
  2. *Designated NGSS1. **Designated NGSS2