Fig. 2From: Association of NAT2 genetic polymorphism with the efficacy of Neurotropin® for the enhancement of aggrecan gene expression in nucleus pulposus cells: a pilot studyPhenotype and age-related changes in the mRNA expression of ACAN induced by NTP treatment. The fold changes in the mRNA expression of ACAN induced by NTP treatment compared with the control in cultured NP cells are shown (N = 31). a Comparison between NAT2 phenotypes. Blue denotes the rapid acetylator phenotype (Rap., N = 18) and orange denotes the intermediate acetylator phenotype (Int., N = 13). There was a significant increase compared with the control in the intermediate acetylator phenotype (P = 0.002). b The data from a are plotted against the age (years) of the donors. There was a weakly negative correlation with age in the rapid acetylator phenotype (P = 0.002) and in all data (P = 0.0021). The blue and orange symbols are as described in aBack to article page