Association of NAT2 genetic polymorphism with the efficacy of Neurotropin® for the enhancement of aggrecan gene expression in nucleus pulposus cells: a pilot study

Table 1 Distribution of NAT2 haplotypes in the cell donors and the Japanese population

Allele	Nucleotide change(s)	Amino acid change(s)	Type	Freq. (%) detected	Freq. (%) literature^a	P value ^b
NAT2*4	–	–	Rapid	79.0	69.5	0.125
NAT2*5B	T341C, C481T, A803G	Ile114Thr, Lys268Arg	Slow	1.6	0.5	0.317
NAT2*6A	C282T, G590A	Arg197Gln	Slow	9.7	19.8	0.056
NAT2*7B	C282T, G857A	Gly286Glu	Slow	9.7	8.8	0.811

^aAllele frequency in the literature, the data was from healthy 200 volunteers ranged 20–60 years old
^bCalculated for haplotype frequencies

ISSN: 1755-8794