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Table 4 NIPT performance for detecting trisomies 21, 18, 13 and sex chromosome aneuploidies in 800 twin and 6 triplet pregnancies

From: Performance of cell-free DNA sequencing-based non-invasive prenatal testing: experience on 36,456 singleton and multiple pregnancies

Twins n = 800 TP FP TN Reported FN Sensitivity Specificity PPV NPV
TP/(TP + FN) TN/(TN + FP) TP/(TP + FP) TN/(TN + FN)
%(95% Cl) %(95% Cl) % (95% Cl) % (95% Cl)
Trisomy 21 (8) 8 0 792 0 100
8/8
100
792/792
100
8/8
100
792/792
      (59.7,100.0) (99.39, 100.0) (59.7, 100.0) (99.39, 100.0)
Trisomy 18 (2) 2 0 798 0 100
2/2
100
798/798
100
2/2
100
798/798
      (19.79, 100) (99.40, 100) (19.78, 100.0) (99.40, 100.0)
Trisomy 13 (1) 0 1 799 0   99.77
799/800
  100
799/799
       (99.13, 100.0)   (99.99, 100.0)
Triplets n = 6         
Trisomy 21 (1) 1 0 0 0     
  1. CI confidence interval, TP true positive, FP false positive, FN false negative