Table 5 NIPT Performance for Detecting Trisomies 21, 18, 13 and Sex Chromosome Aneuploidies in ART Pregnancies
ART pregnancies n = 1807 | TP | FP | TN | Reported FN | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|---|---|---|---|
TP/(TP + FN) | TN/(TN + FP) | TP/(TP + FP) | TN/(TN + FN) | |||||
%(95% Cl) | %(95% Cl) | %(95% Cl) | %(95% Cl) | |||||
T21 | 9 | 0 | 1798 | 0 | 100 9/9 | 100 1798/1798 | 100 9/9 | 100 1798/1798 |
(62.88,100.0) | (99.73, 100.0) | (62.88, 100.0) | (99.79, 100.0) | |||||
T18 | 2 | 0 | 1805 | 0 | 100 2/2 | 100 1805/1805 | 100 2/2 | 100 1805/1805 |
(19.79,100.0) | (99.73, 100.0) | (19.78, 100.0) | (99.73, 100.0) | |||||
T13 | 0 | 1 | 1806 | 0 | 99.94 1806/1807 | – | 100 1806/1806 | |
(99.51, 99.98) | (99.99, 100.0) | |||||||
SCA | 7 | 3 | 1797 | 0 | 100 7/7 | 99.83 1797/1800 | 70 7/10 | 100 1797/1797 |
(64.57,100.0) | (99.23, 99.91) | (41.58, 98.42) | (99.99, 100.0) |