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Table 2 Characteristics of 24 hub genes obtained from a significant module of the PPI network

From: Identification of genes and pathways involved in malignant pleural mesothelioma using bioinformatics methods

Name Full name Degree Regulation MCODE node status
EZH2 Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit 35 Up Clustered
KIF11 Kinesin Family Member 11 27 Up Clustered
ASPM Abnormal Spindle Microtubule Assembly 26 Up Clustered
HMMR Hyaluronan Mediated Motility Receptor 25 Up Seed
CEP55 Centrosomal Protein 55 25 Up Clustered
CDC20 Cell Division Cycle 20 25 Up Clustered
BUB1B BUB1 Mitotic Checkpoint Serine/Threonine Kinase B 25 Up Clustered
PRC1 Protein Regulator Of Cytokinesis 1 25 Up Clustered
RRM2 Ribonucleotide Reductase Regulatory Subunit M2 24 Up Clustered
TOP2A DNA Topoisomerase II Alpha 24 Up Clustered
PBK PDZ Binding Kinase 24 Up Clustered
KIF20A Kinesin Family Member 20A 24 Up Clustered
MCM2 Minichromosome Maintenance Complex Component 2 24 Up Clustered
KIF23 Kinesin Family Member 23 24 Up Clustered
NUSAP1 Nucleolar And Spindle Associated Protein 1 24 Up Clustered
NCAPG Non-SMC Condensin I Complex Subunit G 24 Up Clustered
KIF15 Kinesin Family Member 15 23 Up Clustered
MELK Maternal Embryonic Leucine Zipper Kinase 23 Up Clustered
NDC80 NDC80 Kinetochore Complex Component 23 Up Clustered
CENPF Centromere Protein F 22 Up Clustered
KNTC1 Kinetochore Associated 1 22 Up Clustered
KIF18B Kinesin Family Member 18B 21 Up Clustered
E2F8 E2F Transcription Factor 8 21 Up Clustered
GINS1 GINS Complex Subunit 1 19 Up Clustered
  1. MCODE node status Molecular Complex Detection Node Status