Table 2 Characteristics of 24 hub genes obtained from a significant module of the PPI network
Name | Full name | Degree | Regulation | MCODE node status |
|---|---|---|---|---|
EZH2 | Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit | 35 | Up | Clustered |
KIF11 | Kinesin Family Member 11 | 27 | Up | Clustered |
ASPM | Abnormal Spindle Microtubule Assembly | 26 | Up | Clustered |
HMMR | Hyaluronan Mediated Motility Receptor | 25 | Up | Seed |
CEP55 | Centrosomal Protein 55 | 25 | Up | Clustered |
CDC20 | Cell Division Cycle 20 | 25 | Up | Clustered |
BUB1B | BUB1 Mitotic Checkpoint Serine/Threonine Kinase B | 25 | Up | Clustered |
PRC1 | Protein Regulator Of Cytokinesis 1 | 25 | Up | Clustered |
RRM2 | Ribonucleotide Reductase Regulatory Subunit M2 | 24 | Up | Clustered |
TOP2A | DNA Topoisomerase II Alpha | 24 | Up | Clustered |
PBK | PDZ Binding Kinase | 24 | Up | Clustered |
KIF20A | Kinesin Family Member 20A | 24 | Up | Clustered |
MCM2 | Minichromosome Maintenance Complex Component 2 | 24 | Up | Clustered |
KIF23 | Kinesin Family Member 23 | 24 | Up | Clustered |
NUSAP1 | Nucleolar And Spindle Associated Protein 1 | 24 | Up | Clustered |
NCAPG | Non-SMC Condensin I Complex Subunit G | 24 | Up | Clustered |
KIF15 | Kinesin Family Member 15 | 23 | Up | Clustered |
MELK | Maternal Embryonic Leucine Zipper Kinase | 23 | Up | Clustered |
NDC80 | NDC80 Kinetochore Complex Component | 23 | Up | Clustered |
CENPF | Centromere Protein F | 22 | Up | Clustered |
KNTC1 | Kinetochore Associated 1 | 22 | Up | Clustered |
KIF18B | Kinesin Family Member 18B | 21 | Up | Clustered |
E2F8 | E2F Transcription Factor 8 | 21 | Up | Clustered |
GINS1 | GINS Complex Subunit 1 | 19 | Up | Clustered |