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Table 3 Comparison of prenatal diagnosis willingness and pregnancy outcomes

From: Expanded noninvasive prenatal testing for fetal aneuploidy and copy number variations and parental willingness for invasive diagnosis in a cohort of 18,516 cases

Group Number of high-risk cases Accepted invasive testing Declined invasive testing Number of confirmed cases Terminate pregnancy Continue pregnancy
Common aneuploidies 267 221(82.77%) 46(17.23%) 177 177(100%) 0(0%)
T21 178 153(85.96%) 25(14.04%) 139 139(100%) 0(0%)
T18 51 37(72.55%) 14(27.45%) 29 29(100%) 0(0%)
T13 38 31(81.58%) 7(18.42%) 9 9(100%) 0(0%)
Fetal SCAs 179*** 118(65.92%) 61(34.08%) 24*** 5(20.83%) 19(79.17%)
45,X 82*** 51(62.2%) 31(37.8%) 5*** 1(20%) 4(80%)
47,XXX 25*** 12(48%) 13(52%) 13 NA NA
47,XXY 48 34(70.83%) 14(29.17%) 12*** 2(16.67%) 10(83.33%)
47,XYY 24 21(87.5%) 3(12.5%) 7*** 2(28.57%) 5(71.43%)
RATs 54*** 33(61.11%) 21(38.89%) 3 NA NA
CNVs 33*** 16(48.48%) 17(51.52%) 8*** 6(75%) 2(25%)
CNVs (< 10 M) 12* 7(58.33%) 5(41.67%) 3*** 1(33.33%) 2(66.67%)
CNVs(> 10 M) 21*** 9(42.86%) 12(57.14%) 5 5(100%) 0
  1. *< 0.05, ***< 0.005, Fisher’s exact test. The differences in the rate of prenatal diagnosis and termination of pregnancy were compared between the common aneuploidies group and any other group