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Table 4 Associations between PRSs and PA risk

From: Susceptibility loci for pancreatic cancer in the Brazilian population

Type of score Quintiles ORa 95%CIa p value
Unweighted, subjects with 100% call rate 1 1.00 Ref
  2 0.44 0.09–2.25 0.327
  3 2.61 0.97–7.01 0.057
  4 3.29 1.15–9.37 0.026
  5 6.83 2.76–16.89 3.26 × 10–5
  Continuousb 1.73 1.40–2.15 4.30 × 10–7
Unweighted scaled, all subjects 1 1.00 Ref
  2 0.65 0.16–2.60 0.539
  3 2.22 0.86–5.73 0.097
  4 4.03 1.57–10.37 0.004
  5 6.70 2.86–15.69 1.21 × 10–5
  Continuousb 1.72 1.41–2.10 1.02 × 10–7
Weighted, subjects with 100% call rate 1 1.00 Ref
  2 2.15 0.39–11.75 0.376
  3 3.51 0.71–17.29 0.122
  4 4.90 1.02–23.56 0.047
  5 16.77 3.80–74.07 1.99 × 10–4
  Continuousb 2.05 1.58–2.65 4.98 × 10–8
Weighted scaled, all subjects 1 1.00 Ref
  2 1.37 0.41–4.62 0.613
  3 2.07 0.67–6.44 0.209
  4 3.22 1.08–9.60 0.036
  5 8.13 2.95–22.43 5.12 × 10–5
  Continuousb 1.76 1.42–2.17 2.28 × 10–7
  1. M, major allele; m, minor allele for each SNP; MAF, minor allele frequency
  2. aOR: odds ratio; CI: confidence interval; all analyses were adjusted for age and sex
  3. bThe unit for the analysis with the continuous variable was the increment of one quintile