Gene network analyses unveil possible molecular basis underlying drug-induced glaucoma

BMC Medical Genomics

Table 1 The information of 13 glaucoma-associated genes

Group	Gene	Tissue/cell specificity	Possible function in DIG
Phototransduction-related	CRX	Photoreceptor cells in the retina	Regulates photoreceptor-specific genes [19]
	PDC	Rod cells in the retina	Regulates the phototransduction cascades [20]
	CNGB1	Rod photoreceptor outer segment	Facilitates the regulation of ion flow [21]
	GUCY2F	Photoreceptor cells in the retina	Regulates the state transition of phototransduction [19]
	OPN1SW	Cone cells in the retina	Responds to normal color vision and activates phototransduction cascades [22]
	GNGT1	Retinal rod outer segment cells	Influences the formation and transmission of vision information [22]
	PDE6A	Retinal rod outer segment cells	Conducts and expands visual signals [23]
Glutamate receptor	GRIK3	Brain, eye, endocrine tissues	Mediates glutamate-mediated neural signals between photoreceptors and bipolar cells [24]
	GRIN2B
	GRIK4
5-Hydroxytryptamine receptor	HTR1A	Brain	Influences the intraocular pressure and the activity of RGCs [25]
	HTR1E
	HTR7

ISSN: 1755-8794