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Table 1 The information of 13 glaucoma-associated genes

From: Gene network analyses unveil possible molecular basis underlying drug-induced glaucoma

Group Gene Tissue/cell specificity Possible function in DIG
Phototransduction-related CRX Photoreceptor cells in the retina Regulates photoreceptor-specific genes [19]
PDC Rod cells in the retina Regulates the phototransduction cascades [20]
CNGB1 Rod photoreceptor outer segment Facilitates the regulation of ion flow [21]
GUCY2F Photoreceptor cells in the retina Regulates the state transition of phototransduction [19]
OPN1SW Cone cells in the retina Responds to normal color vision and activates phototransduction cascades [22]
GNGT1 Retinal rod outer segment cells Influences the formation and transmission of vision information [22]
PDE6A Retinal rod outer segment cells Conducts and expands visual signals [23]
Glutamate receptor GRIK3 Brain, eye, endocrine tissues Mediates glutamate-mediated neural signals between photoreceptors and bipolar cells [24]
GRIN2B
GRIK4
5-Hydroxytryptamine receptor HTR1A Brain Influences the intraocular pressure and the activity of RGCs [25]
HTR1E
HTR7