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Table 2 List of the 80 differential expressed proteins in PCOS patients plasma

From: DIA proteomics analysis through serum profiles reveals the significant proteins as candidate biomarkers in women with PCOS

No

Protein accessions

Proteins

Proteins

FDR adj p value PCOS_Con

PCOS/Con ratio

− Log10 (FDR adj p value PCOS/Con)

1

O60814

H2B

Histone H2B

1.87E−03

3.852

2.729

2

P04908

H2A

Histone H2A

3.29E−07

3.658

6.482

3

P11277

SPTB

Spectrin beta chain, erythrocytic

1.13E−03

3.475

2.945

4

P02730

SLC4A1

Band 3 anion transport protein

2.70E−05

3.279

4.569

5

P62805

H4

Histone H4

4.47E−09

2.784

8.350

6

P05388

RPLP0

60S acidic ribosomal protein P0

1.30E−02

2.660

1.886

7

O75460

ERN1

Serine/threonine-protein kinase/endoribonuclease IRE1

1.66E−02

2.201

1.781

8

P30041

PRDX6

Peroxiredoxin-6

6.48E−03

2.160

2.189

9

B9A064

IGLL5

Immunoglobulin lambda-like polypeptide 5

3.17E−02

2.154

1.498

10

P04040

CAT

Catalase

2.76E−02

1.934

1.559

11

P00738

HP

Haptoglobin

4.10E−02

1.926

1.387

12

P13716

ALAD

Delta-aminolevulinic acid dehydratase

2.41E−02

1.903

1.618

13

Q9P2P1

NYNRIN

Protein NYNRIN

3.62E−02

1.875

1.441

14

P01857

IGHG1

Ig gamma-1 chain C region

4.16E−02

1.835

1.380

15

Q06830

PRDX1

Peroxiredoxin-1

5.92E−05

1.832

4.228

16

P32119

PRDX2

Peroxiredoxin-2

9.11E−03

1.629

2.040

17

P05062

ALDOB

Fructose-bisphosphate aldolase B

3.85E−02

1.614

1.415

18

P30043

BLVRB

Flavin reductase (NADPH)

1.48E−02

1.612

1.830

19

P00918

CA2

Carbonic anhydrase 2

1.66E−02

1.563

1.781

20

Q15293

RCN1

Reticulocalbin-1

3.62E−02

1.450

1.441

21

P00558

PGK1

Phosphoglycerate kinase 1

4.75E−02

1.376

1.323

22

P02751

FN1

Fibronectin

1.25E−03

1.298

2.904

23

Q92954

PRG4

Proteoglycan 4

4.37E−02

1.289

1.359

24

P78417

GSTO1

Glutathione S-transferase omega-1

3.04E−02

1.276

1.517

25

P04275

VWF

von Willebrand factor

2.76E−02

1.275

1.559

26

Q9H3P2

NELFA

Negative elongation factor A

3.45E−02

1.160

1.462

27

Q6UX71

PLXDC2

Plexin domain-containing protein 2

2.94E−02

0.876

1.531

28

P08195

SLC3A2

4F2 cell-surface antigen heavy chain

4.39E−02

0.872

1.357

29

P51884

LUM

Lumican

4.10E−02

0.866

1.388

30

O75882

ATRN

Attractin

4.08E−02

0.864

1.390

31

P20851

C4BPB

C4b-binding protein beta chain

4.66E−02

0.857

1.331

32

P00734

F2

Prothrombin

4.45E−03

0.852

2.351

33

P14151

SELL

L-selectin

2.59E−02

0.851

1.586

34

P06396

GSN

Gelsolin

4.16E−02

0.844

1.380

35

O00533

CHL1

Neural cell adhesion molecule L1-like protein

1.15E−02

0.838

1.938

36

P55058

PLTP

Phospholipid transfer protein

2.88E−02

0.824

1.541

37

P07359

GP1BA

Platelet glycoprotein Ib alpha chain

1.89E−02

0.819

1.723

38

P08253

MMP2

72 kDa type IV collagenase

2.59E−02

0.816

1.586

39

Q14126

DSG2

Desmoglein-2

1.87E−02

0.814

1.728

40

Q9NPH3

IL1RAP

Interleukin-1 receptor accessory protein

8.88E−03

0.811

2.051

41

P07998

RNASE1

Ribonuclease pancreatic

2.59E−02

0.811

1.586

42

P02776

PF4

Platelet factor 4

2.70E−02

0.806

1.569

43

P07996

THBS1

Thrombospondin-1

2.59E−02

0.797

1.586

44

Q07954

LRP1

Prolow-density lipoprotein receptor-related protein 1

3.81E−02

0.793

1.419

45

Q15166

PON3

Serum paraoxonase/lactonase 3

1.66E−02

0.790

1.781

46

P05452

CLEC3B

Tetranectin

9.11E−03

0.789

2.040

47

P10643

C7

Complement component C7

8.88E−03

0.788

2.051

48

P54289

CACNA2D1

Voltage-dependent calcium channel subunit alpha-2/delta-1

3.49E−02

0.780

1.457

49

P05067

APP

Amyloid beta A4 protein

2.70E−02

0.764

1.569

50

Q12860

CNTN1

Contactin-1

1.25E−03

0.762

2.904

51

Q99784

OLFM1

Noelin

3.71E−02

0.758

1.431

52

P40189

IL6ST

Interleukin-6 receptor subunit beta

3.17E−02

0.756

1.498

53

P02671

FGA

Fibrinogen alpha chain

1.25E−03

0.723

2.904

54

P40197

GP5

Platelet glycoprotein V

2.65E−03

0.720

2.576

55

Q9BZE9

ASPSCR1

Tether containing UBX domain for GLUT4

4.13E−02

0.720

1.384

56

Q10588

BST1

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2

3.71E−02

0.688

1.431

57

P13473

LAMP2

Lysosome-associated membrane glycoprotein 2

4.49E−02

0.682

1.348

58

P04066

FUCA1

Tissue alpha-L-fucosidase

4.37E−02

0.680

1.359

59

Q8IVU3

HERC6

Probable E3 ubiquitin-protein ligase HERC6

3.17E−02

0.668

1.498

60

P02786

TFRC

Transferrin receptor protein 1

2.66E−03

0.667

2.575

61

P25311

AZGP1

Zinc-alpha-2-glycoprotein

1.66E−02

0.656

1.781

62

Q8WZ42

TTN

Titin

4.10E−03

0.653

2.388

63

P01009

SERPINA1

Alpha-1-antitrypsin

2.70E−02

0.645

1.569

64

P05090

APOD

Apolipoprotein D

3.17E−02

0.629

1.498

65

P16109

SELP

P-selectin

3.88E−02

0.618

1.412

66

Q15848

ADIPOQ

Adiponectin

4.16E−02

0.607

1.380

67

P04745

AMY1A

Alpha-amylase 1

2.70E−02

0.582

1.569

68

Q16853

AOC3

Membrane primary amine oxidase

2.45E−02

0.575

1.611

69

P54108

CRISP3

Cysteine-rich secretory protein 3

2.11E−02

0.573

1.676

70

P58335

ANTXR2

Anthrax toxin receptor 2

3.17E−02

0.565

1.498

71

Q5VY43

PEAR1

Platelet endothelial aggregation receptor 1

2.13E−02

0.563

1.671

72

P18065

IGFBP2

Insulin-like growth factor-binding protein 2

5.87E−03

0.551

2.231

73

P0DMV8

HSPA1A

Heat shock 70 kDa protein 1A

2.70E−02

0.455

1.569

74

Q86YW5

TLT-1

Trem-like transcript 1 protein

3.11E−07

0.452

6.507

75

P21926

CD9

CD9 antigen

3.64E−03

0.411

2.438

76

P08567

PLEK

Pleckstrin

4.45E−03

0.392

2.351

77

P37802

TAGLN2

Transgelin-2

2.37E−04

0.352

3.626

78

O15394

NCAM2

Neural cell adhesion molecule 2

1.10E−02

0.350

1.957

79

Q15942

ZYX

Zyxin

3.91E−05

0.219

4.408

80

Q8IVT5

KSR1

Kinase suppressor of Ras 1

2.04E−03

0.060

2.691

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BMC Medical Genomics

ISSN: 1755-8794

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