Fig. 2

The Hep and S1 indexes are negatively correlated in tissues from HCC or developing liver. a Hep and S1 indexes from different histologically graded groups of HCC patients. The t-test was applied to compare the Hep and S1 indexes of patients from different groups. *** Signifies P values < 0.001 and * signifies P values < 0.05. b Expression profiles of genes from the S1 and Hep gene signatures and scatter plot of S1 and Hep indexes for HCC tissues. The Pearson correlation coefficient (\(r\)) between the two indexes was calculated, and the P value of \(r\) was estimated. c Expression profiles of genes from the S1 and Hep gene signatures in liver tissues from different development stages. E, D and W denote embryonic day, day and week, respectively. d Plot of S1 and Hep indexes for liver tissues from different development stages. The Pearson correlation coefficient (\(r\)) between the two indexes was calculated, and the P value of \(r\) was estimated