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Table 3 The Association between MTNR1B Variants and Adiposity adjusting for Insomnia

From: Association between MTNR1B polymorphisms and obesity in African American: findings from the Jackson Heart Study

     

Adiposity

Adiposity-Insomnia

 

SNPs

BP

A1

A2

MAF

p value

FDR

p value

OR

LCI

UCI

p value

FDR

p value

OR

LCI

UCI

Type of Mutation

rs12290860

92979012

G

A

0.2240

0.0042

0.0250

0.74

0.54

0.95

0.0012

0.0040

0.66

0.40

0.91

Intronic

rs61747139

92981951

A

G

0.2270

0.0042

0.0250

0.74

0.54

0.95

0.0013

0.0040

0.66

0.41

0.92

Missense

rs6483210

92981429

C

T

0.2270

0.0043

0.0250

0.75

0.54

0.95

0.0013

0.0040

0.66

0.41

0.92

Intronic

rs7127128

92980510

A

G

0.2270

0.0044

0.0250

0.75

0.54

0.95

0.0013

0.0040

0.66

0.41

0.92

Intronic

rs12292400

92979446

G

C

0.2250

0.0055

0.0250

0.75

0.55

0.95

0.0017

0.0047

0.67

0.41

0.92

Intronic

rs6483209

92976223

C

T

0.2120

0.0022

0.0250

0.73

0.52

0.93

0.0003

0.0025

0.62

0.36

0.88

Intronic

rs7130424

92980527

T

C

0.2660

0.0117

0.0281

0.79

0.60

0.97

0.0021

0.0053

0.70

0.46

0.93

Intronic

rs12272268

92975633

C

G

0.2520

0.0075

0.0250

0.77

0.58

0.96

0.0007

0.0040

0.67

0.43

0.91

Intronic

rs12792653

92982750

A

G

0.4460

0.0121

0.0281

0.81

0.64

0.97

0.0872

0.1313

0.83

0.62

1.04

3’-UTR

rs1562444

92982683

A

G

0.4460

0.0122

0.0281

0.81

0.64

0.98

0.0875

0.1313

0.83

0.62

1.04

3’-UTR

rs11020126

92973751

G

A

0.1810

0.0060

0.0250

0.73

0.51

0.96

0.000045

0.0012

0.56

0.27

0.84

Intronic

rs11020125

92973378

T

G

0.1710

0.0070

0.0250

0.74

0.51

0.96

0.0001

0.0012

0.57

0.28

0.86

Intronic

rs12277904

92978680

C

T

0.1370

0.0105

0.0281

0.73

0.48

0.97

0.0115

0.0203

0.68

0.38

0.98

Intronic

rs116625623

92971729

G

T

0.0950

0.0180

0.0385

0.70

0.41

1.00

0.0012

0.0040

0.54

0.17

0.92

Intronic

rs7129768

92980510

G

A

0.0880

0.0202

0.0404

0.70

0.40

1.00

0.0033

0.0075

0.56

0.18

0.95

Intronic

rs76371840

92971529

C

T

0.0740

0.0266

0.0499

1.48

1.13

1.82

0.0423

0.0705

1.54

1.12

1.96

Intronic

rs6483208

92972678

T

G

0.2200

0.0291

0.0514

0.80

0.60

1.00

0.0003

0.0025

0.63

0.38

0.89

Intronic

rs4388843

92971820

G

A

0.3110

0.2311

0.3015

0.90

0.72

1.08

0.0058

0.0123

0.73

0.50

0.95

Intronic

rs4601728

92971992

A

G

0.3130

0.2432

0.3040

0.90

0.72

1.08

0.0066

0.0132

0.73

0.51

0.96

Intronic

rs12804291

92972141

C

T

0.2650

0.2203

0.3005

0.89

0.71

1.08

0.0092

0.0172

0.73

0.50

0.97

Intronic

  1. Adiposity for adjusted age, sex, and ancestry; Adiposity-Insomnia for Adiposity model with adjustment for Insomnia. The results of the associations are listed as Odds Ratio (OR) with the Lower and Upper Confidence Interval (LCI and UCI) and the corresponding adjusted False Discovery Rate (FDR) p value. A1 and A2 are reference allele and alternative allele; MAF is Minor Allele Frequency; BP is Base Pair