Skip to main content

Table 3 Alleles that undergo somatic selection in cancers are enriched for deleterious alleles

From: Exonic variants undergoing allele-specific selection in cancers

Somatic selection Cancer type Significance level of \({\pi }_{i}\) Fraction of deleterious alleles undergo somatic selection Fraction of deleterious alleles in exonic alleles Ratio P value
Selected-for BRCA 0.001 0.286 0.426 0.670 6.361e-01
0.01 0.533 0.426 1.251 2.362e-02
0.05 0.516 0.426 1.211 1.914e-04
COAD 0.001 0.800 0.423 1.893 1.347e-02
0.01 0.617 0.423 1.461 1.349e-04
0.05 0.525 0.423 1.241 4.558e-06
LUAD 0.001 0.400 0.441 0.908 5.186e-01
0.01 0.509 0.441 1.155 6.151e-02
0.05 0.481 0.441 1.091 3.543e-02
PRAD 0.001 NA 0.436 NA NA
0.01 NA 0.436 NA NA
0.05 0.500 0.436 1.148 1.673e-01
Selected-against BRCA 0.001 0.370 0.426 0.869 6.497e-01
0.01 0.471 0.426 1.105 1.250e-01
0.05 0.503 0.426 1.181 4.496e-05
COAD 0.001 0.286 0.423 0.676 6.284e-01
0.01 0.510 0.423 1.208 3.282e-02
0.05 0.477 0.423 1.129 5.585e-03
LUAD 0.001 0.472 0.441 1.070 2.753e-01
0.01 0.505 0.441 1.146 1.024e-02
0.05 0.493 0.441 1.118 3.740e-04
PRAD 0.001 0.500 0.436 1.148 1.898e-01
0.01 0.538 0.436 1.236 1.522e-01
0.05 0.356 0.436 0.817 9.524e-01