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Fig. 4 | BMC Medical Genomics

Fig. 4

From: Identification of key genes in calcific aortic valve disease via weighted gene co-expression network analysis

Fig. 4

The identification of key modules via weighted gene co-expression network analysis. a Heatmap of the correlation between module eigengenes and the disease status of CAVD. The corresponding correlation coefficient along with P-value is given in each cell, and each cell is color-coded by correlation according to the color (legend at right). b Barplot of mean gene significance across modules associated with CAVD. A higher mean gene significance indicates that the module is more significantly related to CAVD. The blue and yellow modules were the most significantly correlated with CAVD. Scatter plot of module eigengenes in the c blue module and d yellow module. e Module preservation analysis based on Zsummary. Each point represents a module, and the dashed blue and green lines indicate the threshold of 2 and 10, respectively. A module with a Zsummary of < 5 would be considered non-preserved. f The principal component analysis of the genes in blue and yellow modules. CAVD calcific aortic valve disease, PCA principal component analysis

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