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Fig. 6 | BMC Medical Genomics

Fig. 6

From: Identification of key genes in calcific aortic valve disease via weighted gene co-expression network analysis

Fig. 6

PPI network construction and identification of hub genes. a The Venn diagram of key genes from the key modules and DEGs from GSE83453, GSE51472, and GSE12644. b The protein–protein interaction network of the overlapped genes. c 5 hub genes identified by ‘cytoHubba’ according to mixed character calculation. The significance of hub genes gradually increases from yellow to red. d The expression levels of hub genes in calcified or normal aortic valve samples from GSE83453. Boxplots show the median, 25–75% percentiles, and range of log2 expression value. *P < 0.05; **P < 0.01; ***P < 0.001 (Student’s t-test)

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