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Fig. 4 | BMC Medical Genomics

Fig. 4

From: Identification of potential therapeutic targets for atherosclerosis by analysing the gene signature related to different immune cells and immune regulators in atheromatous plaques

Fig. 4

Gene set enrichment analysis (GSEA) comparing atheromatous plaques in the ImmuneScoreH cluster with those in the ImmuneScoreL cluster of GSE100927. AF KEGG canonical pathways were used as the a priori knowledge for the GSEA. A Primary immunodeficiency, B leukocyte transendothelial migration, C antigen processing and presentation, D natural killer cell-mediated cytotoxicity, E T cell receptor signalling pathway, and F B cell receptor signalling pathway were highly enriched in the ImmuneScoreH cluster. GL The REACTOME subset of canonical pathways was used as the a priori information for the GSEA. GJ Interferon-related pathways, K PD-1 signalling, and L neutrophil degranulation were highly enriched in the ImmuneScoreH cluster

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