Fig. 4

Gene set enrichment analysis (GSEA) comparing atheromatous plaques in the ImmuneScoreH cluster with those in the ImmuneScoreL cluster of GSE100927. A–F KEGG canonical pathways were used as the a priori knowledge for the GSEA. A Primary immunodeficiency, B leukocyte transendothelial migration, C antigen processing and presentation, D natural killer cell-mediated cytotoxicity, E T cell receptor signalling pathway, and F B cell receptor signalling pathway were highly enriched in the ImmuneScoreH cluster. G–L The REACTOME subset of canonical pathways was used as the a priori information for the GSEA. G–J Interferon-related pathways, K PD-1 signalling, and L neutrophil degranulation were highly enriched in the ImmuneScoreH cluster