Fig. 4From: A novel mutation of COL2A1 in a large Chinese family with avascular necrosis of the femoral headA The sequencing revealed a heterozygous 1 bp missense (c.3517G > A) in exon 50, which resulted in p.Gly1173Ser. B It is non-conservative, affects evolutionarily highly conserved amino acids from fish to mammalsBack to article page