SNP ID
|
Model
|
genotype
|
Case
|
Control
|
OR (95% CI)
|
p
|
Case
|
Control
|
OR (95% CI)
|
p
|
---|
Age, years
| | |
> 60
| | | |
≤ 60
| | | |
rs3821236
|
Allele
|
G
|
212
|
232
|
1.00
| |
267
|
196
|
1.00
| |
| |
A
|
268
|
304
|
1.04 (0.81–1.33)
|
0.777
|
253
|
270
|
1.45 (1.13–1.87)
|
0.004
|
|
Genotype
|
GG
|
73
|
90
|
1.00
| |
61
|
76
|
1.00
| |
| |
AA
|
45
|
54
|
0.91 (0.54–1.54)
|
0.729
|
68
|
39
|
2.16 (1.28–3.64)
|
0.004
|
| |
AG
|
122
|
124
|
1.15 (0.76–1.73)
|
0.507
|
131
|
118
|
1.39 (0.91–2.12)
|
0.127
|
|
Dominant
|
GG
|
73
|
90
|
1.00
| |
61
|
76
|
1.00
| |
| |
AA-AG
|
167
|
178
|
1.08 (0.73–1.58)
|
0.710
|
199
|
157
|
1.58 (1.06–2.35)
|
0.025
|
|
Recessive
|
AG-GG
|
195
|
214
|
1.00
| |
192
|
194
|
1.00
| |
| |
AA
|
45
|
54
|
0.84 (0.53–1.33)
|
0.454
|
68
|
39
|
1.75 (1.12–2.73)
|
0.014
|
|
Log-additive
|
-
|
-
|
-
|
0.98 (0.76–1.26)
|
0.864
|
-
|
-
|
1.46 (1.13–1.90)
|
0.004
|
rs11893432
|
Allele
|
C
|
214
|
239
|
1.00
| |
269
|
203
|
1.00
| |
| |
G
|
266
|
297
|
1.00 (0.78–1.28)
|
0.998
|
251
|
263
|
1.39 (1.08–1.79)
|
0.010
|
|
Genotype
|
CC
|
74
|
85
|
1.00
| |
59
|
72
|
1.00
| |
| |
GG
|
48
|
56
|
0.89 (0.53–1.49)
|
0.664
|
68
|
42
|
1.97 (1.17–3.32)
|
0.010
|
| |
CG
|
118
|
127
|
1.00 (0.66–1.51)
|
1.000
|
133
|
119
|
1.39 (0.91–2.13)
|
0.130
|
|
Dominant
|
CC
|
74
|
85
|
1.00
| |
59
|
72
|
1.00
| |
| |
GG-GC
|
166
|
183
|
0.97 (0.66–1.43)
|
0.866
|
201
|
161
|
1.54 (1.03–2.31)
|
0.036
|
|
Recessive
|
GC-CC
|
192
|
212
|
1.00
| |
192
|
191
|
1.00
| |
| |
GG
|
48
|
56
|
0.84 (0.53–1.33)
|
0.454
|
68
|
42
|
1.59 (1.03–2.46)
|
0.038
|
|
Log-additive
|
-
|
-
|
-
|
0.95 (0.74–1.23)
|
0.695
|
-
|
-
|
1.40 (1.08–1.82)
|
0.010
|
rs11889341
|
Allele
|
C
|
158
|
181
|
1.00
| |
197
|
148
|
1.00
| |
| |
T
|
322
|
355
|
0.96 (0.74–1.25)
|
0.774
|
323
|
314
|
1.29 (0.99–1.69)
|
0.055
|
|
Genotype
|
CC
|
107
|
119
|
1.00
| |
91
|
102
|
1.00
| |
| |
TT
|
25
|
32
|
0.87 (0.47–1.60)
|
0.644
|
28
|
19
|
1.60 (0.83–3.06)
|
0.161
|
| |
TC
|
108
|
117
|
1.01 (0.69–1.48)
|
0.944
|
141
|
110
|
1.46 (1.00–2.13)
|
0.052
|
|
Dominant
|
CC
|
107
|
119
|
1.00
| |
91
|
102
|
1.00
| |
| |
TT-TC
|
133
|
149
|
0.98 (0.68–1.41)
|
0.925
|
169
|
129
|
1.48 (1.03–2.13)
|
0.037
|
|
Recessive
|
TC-CC
|
215
|
236
|
1.00
| |
232
|
212
|
1.00
| |
| |
TT
|
25
|
32
|
0.86 (0.48–1.54)
|
0.611
|
28
|
19
|
1.29 (0.70–2.39)
|
0.416
|
|
Log-additive
|
-
|
-
|
-
|
0.96 (0.73–1.26)
|
0.757
|
-
|
-
|
1.34 (1.01–1.78)
|
0.046
|
rs7574865
|
Allele
|
G
|
154
|
173
|
1.00
| |
193
|
154
|
1.00
| |
| |
T
|
326
|
361
|
0.99 (0.76–1.28)
|
0.915
|
327
|
312
|
1.20 (0.92–1.56)
|
0.182
|
|
Genotype
|
GG
|
109
|
121
|
1.00
| |
93
|
99
|
1.00
| |
| |
TT
|
23
|
27
|
1.01 (0.54–1.91)
|
0.972
|
26
|
20
|
1.32 (0.68–2.53)
|
0.412
|
| |
TG
|
108
|
119
|
1.01 (0.69–1.47)
|
0.967
|
141
|
114
|
1.33 (0.91–1.94)
|
0.138
|
|
Dominant
|
GG
|
109
|
121
|
1.00
| |
93
|
99
|
1.00
| |
| |
TT-TG
|
131
|
146
|
1.01 (0.70–1.45)
|
0.963
|
167
|
134
|
1.33 (0.92–1.91)
|
0.127
|
|
Recessive
|
TG-GG
|
217
|
240
|
1.00
| |
234
|
213
|
1.00
| |
| |
TT
|
23
|
27
|
1.01 (0.55–1.85)
|
0.981
|
26
|
20
|
1.12 (0.60–2.08)
|
0.722
|
|
Log-additive
|
-
|
-
|
-
|
1.01 (0.76–1.33)
|
0.963
|
-
|
-
|
1.22 (0.92–1.62)
|
0.177
|
rs897200
|
Allele
|
T
|
236
|
265
|
1.00
| |
245
|
224
|
1.00
| |
| |
C
|
244
|
271
|
0.99 (0.77–1.27)
|
0.931
|
275
|
242
|
0.96 (0.75–1.24)
|
0.765
|
|
Genotype
|
TT
|
65
|
69
|
1.00
| |
75
|
58
|
1.00
| |
| |
CC
|
61
|
66
|
1.13 (0.68–1.88)
|
0.626
|
60
|
49
|
0.91 (0.54–1.52)
|
0.713
|
| |
CT
|
114
|
133
|
1.00 (0.64–1.54)
|
0.990
|
125
|
126
|
0.75 (0.49–1.15)
|
0.191
|
|
Dominant
|
TT
|
65
|
69
|
1.00
| |
75
|
58
|
1.00
| |
| |
CC-CT
|
175
|
199
|
1.04 (0.69–1.57)
|
0.847
|
185
|
175
|
0.80 (0.53–1.19)
|
0.268
|
|
Recessive
|
CT-TT
|
179
|
202
|
1.00
| |
200
|
184
|
1.00
| |
| |
CC
|
61
|
66
|
1.14 (0.75–1.72)
|
0.549
|
60
|
49
|
1.10 (0.71–1.69)
|
0.677
|
|
Log-additive
|
-
|
-
|
-
|
1.06 (0.83–1.37)
|
0.630
|
-
|
-
|
0.94 (0.73–1.22)
|
0.648
|
SNP ID
|
Model
|
genotype
|
Case
|
Control
|
OR (95% CI)
|
p
|
Case
|
Control
|
OR (95% CI)
|
p
|
---|
Gender
| | |
Male
| | | |
Female
| | | |
rs3821236
|
Allele
|
G
|
336
|
302
|
1.00
| |
143
|
126
|
1.00
| |
| |
A
|
380
|
414
|
1.21 (0.98–1.49)
|
0.071
|
141
|
160
|
1.29 (0.93–1.79)
|
0.154
|
|
Genotype
|
GG
|
101
|
122
|
1.00
| |
33
|
44
|
1.00
| |
| |
AA
|
79
|
66
|
1.45 (0.95–2.20)
|
0.085
|
34
|
27
|
1.69 (0.85–3.33)
|
0.132
|
| |
AG
|
178
|
170
|
1.27 (0.90–1.77)
|
0.172
|
75
|
72
|
1.39 (0.80–2.40)
|
0.245
|
|
Dominant
|
GG
|
101
|
122
|
1.00
| |
33
|
44
|
1.00
| |
| |
AA-AG
|
257
|
236
|
1.32 (0.96–1.81)
|
0.090
|
109
|
99
|
1.47 (0.87–2.49)
|
0.153
|
|
Recessive
|
AG-GG
|
279
|
292
|
1.00
| |
108
|
116
|
1.00
| |
| |
AA
|
79
|
66
|
1.25 (0.87–1.81)
|
0.227
|
34
|
27
|
1.36 (0.77–2.40)
|
0.295
|
|
Log-additive
|
-
|
-
|
-
|
1.21 (0.98–1.49)
|
0.073
|
-
|
-
|
1.30 (0.93–1.83)
|
0.125-
|
rs11893432
|
Allele
|
C
|
338
|
322
|
1.00
| |
145
|
120
|
1.00
| |
| |
G
|
378
|
394
|
1.09 (0.89–1.35)
|
0.396
|
139
|
166
|
1.44 (1.04–2.01)
|
0.029
|
|
Genotype
|
CC
|
100
|
111
|
1.00
| |
33
|
46
|
1.00
| |
| |
GG
|
80
|
75
|
1.18 (0.78–1.79)
|
0.425
|
36
|
23
|
2.19 (1.10–4.37)
|
0.026
|
| |
GC
|
178
|
172
|
1.15 (0.82–1.62)
|
0.427
|
73
|
74
|
1.38 (0.79–2.40)
|
0.254
|
|
Dominant
|
CC
|
100
|
111
|
1.00
| |
33
|
46
|
1.00
| |
| |
GG-GC
|
258
|
247
|
1.16 (0.84–1.60)
|
0.367
|
109
|
97
|
1.57 (0.93–2.66)
|
0.092
|
|
Recessive
|
GC-CC
|
278
|
283
|
1.00
| |
106
|
120
|
1.00
| |
| |
GG
|
80
|
75
|
1.09 (0.76–1.55)
|
0.650
|
36
|
23
|
1.78 (0.99–3.19)
|
0.054
|
|
Log-additive
|
-
|
-
|
-
|
1.09 (0.89–1.34)
|
0.400
|
-
|
-
|
1.47 (1.05–2.07)
|
0.027
|
rs11889341
|
Allele
|
C
|
257
|
236
|
1.00
| |
98
|
93
|
1.00
| |
| |
T
|
459
|
476
|
1.13 (0.91–1.41)
|
0.275
|
186
|
193
|
1.09 (0.77–1.55)
|
0.615
|
|
Genotype
|
CC
|
140
|
157
|
1.00
| |
58
|
64
|
1.00
| |
| |
TT
|
39
|
37
|
1.18 (0.71–1.96)
|
0.516
|
14
|
14
|
1.11 (0.49–2.52)
|
0.810
|
| |
TC
|
179
|
162
|
1.24 (0.91–1.69)
|
0.178
|
70
|
65
|
1.19 (0.73–1.94)
|
0.489
|
|
Dominant
|
CC
|
140
|
157
|
1.00
| |
58
|
64
|
1.00
| |
| |
TT-TC
|
218
|
199
|
1.23 (0.91–1.66)
|
0.176
|
84
|
79
|
1.18 (0.73–1.88)
|
0.502
|
|
Recessive
|
TC-CC
|
319
|
319
|
1.00
| |
128
|
129
|
1.00
| |
| |
TT
|
39
|
37
|
1.06 (0.66–1.70)
|
0.827
|
14
|
14
|
1.01 (0.46–2.21)
|
0.981
|
|
Log-additive
|
-
|
-
|
-
|
1.14 (0.91–1.43)
|
0.261
|
-
|
-
|
1.10 (0.77–1.58)
|
0.599
|
rs7574865
|
Allele
|
G
|
252
|
233
|
1.00
| |
95
|
94
|
1.00
| |
| |
T
|
464
|
483
|
1.13 (0.90–1.40)
|
0.289
|
189
|
190
|
1.02 (0.72–1.44)
|
0.929
|
|
Genotype
|
GG
|
142
|
158
|
1.00
| |
60
|
62
|
1.00
| |
| |
TT
|
36
|
33
|
1.26 (0.72–2.05)
|
0.467
|
13
|
14
|
0.96 (0.42–2.23)
|
0.933
|
| |
TG
|
180
|
167
|
1.20 (0.88–1.64)
|
0.249
|
69
|
66
|
1.08 (0.66–1.77)
|
0.752
|
|
Dominant
|
GG
|
142
|
158
|
1.00
| |
60
|
62
|
1.00
| |
| |
TT-TG
|
216
|
200
|
1.20 (0.89–1.62)
|
0.225
|
82
|
80
|
1.06 (0.66–1.70)
|
0.802
|
|
Recessive
|
TG-GG
|
322
|
325
|
1.00
| |
13
|
14
|
1.00
| |
| |
TT
|
36
|
33
|
1.10 (0.67–1.81)
|
0.704
|
129
|
128
|
0.92 (0.42–2.05)
|
0.848
|
|
Log-additive
|
-
|
-
|
-
|
1.14 (0.91–1.43)
|
0.268
|
-
|
-
|
1.02 (0.71–1.47)
|
0.916
|
rs897200
|
Allele
|
T
|
346
|
350
|
1.00
| |
141
|
141
|
1.00
| |
| |
C
|
370
|
366
|
0.98 (0.79–1.20)
|
0.833
|
143
|
145
|
1.01 (0.73–1.41)
|
0.934
|
|
Genotype
|
TT
|
102
|
91
|
1.00
| |
35
|
35
|
1.00
| |
| |
CC
|
90
|
83
|
0.97 (0.64–1.46)
|
0.875
|
34
|
33
|
1.03 (0.53–2.01)
|
0.930
|
| |
CT
|
166
|
184
|
0.80 (0.57–1.14)
|
0.227
|
73
|
75
|
0.97 (0.55–1.72)
|
0.927
|
|
Dominant
|
TT
|
102
|
91
|
1.00
| |
35
|
35
|
1.00
| |
| |
CC-CT
|
256
|
267
|
0.86 (0.61–1.19)
|
0.354
|
107
|
108
|
0.99 (0.58–1.70)
|
0.974
|
|
Recessive
|
CT-TT
|
268
|
275
|
1.00
| |
108
|
110
|
1.00
| |
| |
CC
|
90
|
83
|
1.11 (0.79–1.57)
|
0.541
|
34
|
33
|
1.05 (0.61–1.81)
|
0.864
|
|
Log-additive
|
-
|
-
|
-
|
0.98 (0.80–1.20)
|
0.833
|
-
|
-
|
1.02 (0.73–1.42)
|
0.933
|
- CI confidence interval, OR odds ratio
- p: values were calculated by unconditional logistic regression analysis with adjustment for age and gender, *p < 0.05 indicates statistical significance