Association between STAT4 gene polymorphism and type 2 diabetes risk in Chinese Han population

Cui, Jiaqi; Tong, Rui; Xu, Jing; Tian, Yanni; Pan, Juan; Wang, Ning; Chen, Huan; Peng, Yanqi; Fei, Sijia; Ling, Wang; Guo, Chaoying; Yao, Juanchuan; Cui, Wei

doi:10.1186/s12920-021-01000-2

BMC Medical Genomics

Table 4 The SNPs of STAT4 associated with diabetes risk in the subgroup tests

From: Association between STAT4 gene polymorphism and type 2 diabetes risk in Chinese Han population

SNP ID	Model	genotype	Case	Control	OR (95% CI)	p	Case	Control	OR (95% CI)	p
Age, years			> 60				≤ 60
rs3821236	Allele	G	212	232	1.00		267	196	1.00
		A	268	304	1.04 (0.81–1.33)	0.777	253	270	1.45 (1.13–1.87)	0.004
	Genotype	GG	73	90	1.00		61	76	1.00
		AA	45	54	0.91 (0.54–1.54)	0.729	68	39	2.16 (1.28–3.64)	0.004
		AG	122	124	1.15 (0.76–1.73)	0.507	131	118	1.39 (0.91–2.12)	0.127
	Dominant	GG	73	90	1.00		61	76	1.00
		AA-AG	167	178	1.08 (0.73–1.58)	0.710	199	157	1.58 (1.06–2.35)	0.025
	Recessive	AG-GG	195	214	1.00		192	194	1.00
		AA	45	54	0.84 (0.53–1.33)	0.454	68	39	1.75 (1.12–2.73)	0.014
	Log-additive	-	-	-	0.98 (0.76–1.26)	0.864	-	-	1.46 (1.13–1.90)	0.004
rs11893432	Allele	C	214	239	1.00		269	203	1.00
		G	266	297	1.00 (0.78–1.28)	0.998	251	263	1.39 (1.08–1.79)	0.010
	Genotype	CC	74	85	1.00		59	72	1.00
		GG	48	56	0.89 (0.53–1.49)	0.664	68	42	1.97 (1.17–3.32)	0.010
		CG	118	127	1.00 (0.66–1.51)	1.000	133	119	1.39 (0.91–2.13)	0.130
	Dominant	CC	74	85	1.00		59	72	1.00
		GG-GC	166	183	0.97 (0.66–1.43)	0.866	201	161	1.54 (1.03–2.31)	0.036
	Recessive	GC-CC	192	212	1.00		192	191	1.00
		GG	48	56	0.84 (0.53–1.33)	0.454	68	42	1.59 (1.03–2.46)	0.038
	Log-additive	-	-	-	0.95 (0.74–1.23)	0.695	-	-	1.40 (1.08–1.82)	0.010
rs11889341	Allele	C	158	181	1.00		197	148	1.00
		T	322	355	0.96 (0.74–1.25)	0.774	323	314	1.29 (0.99–1.69)	0.055
	Genotype	CC	107	119	1.00		91	102	1.00
		TT	25	32	0.87 (0.47–1.60)	0.644	28	19	1.60 (0.83–3.06)	0.161
		TC	108	117	1.01 (0.69–1.48)	0.944	141	110	1.46 (1.00–2.13)	0.052
	Dominant	CC	107	119	1.00		91	102	1.00
		TT-TC	133	149	0.98 (0.68–1.41)	0.925	169	129	1.48 (1.03–2.13)	0.037
	Recessive	TC-CC	215	236	1.00		232	212	1.00
		TT	25	32	0.86 (0.48–1.54)	0.611	28	19	1.29 (0.70–2.39)	0.416
	Log-additive	-	-	-	0.96 (0.73–1.26)	0.757	-	-	1.34 (1.01–1.78)	0.046
rs7574865	Allele	G	154	173	1.00		193	154	1.00
		T	326	361	0.99 (0.76–1.28)	0.915	327	312	1.20 (0.92–1.56)	0.182
	Genotype	GG	109	121	1.00		93	99	1.00
		TT	23	27	1.01 (0.54–1.91)	0.972	26	20	1.32 (0.68–2.53)	0.412
		TG	108	119	1.01 (0.69–1.47)	0.967	141	114	1.33 (0.91–1.94)	0.138
	Dominant	GG	109	121	1.00		93	99	1.00
		TT-TG	131	146	1.01 (0.70–1.45)	0.963	167	134	1.33 (0.92–1.91)	0.127
	Recessive	TG-GG	217	240	1.00		234	213	1.00
		TT	23	27	1.01 (0.55–1.85)	0.981	26	20	1.12 (0.60–2.08)	0.722
	Log-additive	-	-	-	1.01 (0.76–1.33)	0.963	-	-	1.22 (0.92–1.62)	0.177
rs897200	Allele	T	236	265	1.00		245	224	1.00
		C	244	271	0.99 (0.77–1.27)	0.931	275	242	0.96 (0.75–1.24)	0.765
	Genotype	TT	65	69	1.00		75	58	1.00
		CC	61	66	1.13 (0.68–1.88)	0.626	60	49	0.91 (0.54–1.52)	0.713
		CT	114	133	1.00 (0.64–1.54)	0.990	125	126	0.75 (0.49–1.15)	0.191
	Dominant	TT	65	69	1.00		75	58	1.00
		CC-CT	175	199	1.04 (0.69–1.57)	0.847	185	175	0.80 (0.53–1.19)	0.268
	Recessive	CT-TT	179	202	1.00		200	184	1.00
		CC	61	66	1.14 (0.75–1.72)	0.549	60	49	1.10 (0.71–1.69)	0.677
	Log-additive	-	-	-	1.06 (0.83–1.37)	0.630	-	-	0.94 (0.73–1.22)	0.648

SNP ID	Model	genotype	Case	Control	OR (95% CI)	p	Case	Control	OR (95% CI)	p
Gender			Male				Female
rs3821236	Allele	G	336	302	1.00		143	126	1.00
		A	380	414	1.21 (0.98–1.49)	0.071	141	160	1.29 (0.93–1.79)	0.154
	Genotype	GG	101	122	1.00		33	44	1.00
		AA	79	66	1.45 (0.95–2.20)	0.085	34	27	1.69 (0.85–3.33)	0.132
		AG	178	170	1.27 (0.90–1.77)	0.172	75	72	1.39 (0.80–2.40)	0.245
	Dominant	GG	101	122	1.00		33	44	1.00
		AA-AG	257	236	1.32 (0.96–1.81)	0.090	109	99	1.47 (0.87–2.49)	0.153
	Recessive	AG-GG	279	292	1.00		108	116	1.00
		AA	79	66	1.25 (0.87–1.81)	0.227	34	27	1.36 (0.77–2.40)	0.295
	Log-additive	-	-	-	1.21 (0.98–1.49)	0.073	-	-	1.30 (0.93–1.83)	0.125-
rs11893432	Allele	C	338	322	1.00		145	120	1.00
		G	378	394	1.09 (0.89–1.35)	0.396	139	166	1.44 (1.04–2.01)	0.029
	Genotype	CC	100	111	1.00		33	46	1.00
		GG	80	75	1.18 (0.78–1.79)	0.425	36	23	2.19 (1.10–4.37)	0.026
		GC	178	172	1.15 (0.82–1.62)	0.427	73	74	1.38 (0.79–2.40)	0.254
	Dominant	CC	100	111	1.00		33	46	1.00
		GG-GC	258	247	1.16 (0.84–1.60)	0.367	109	97	1.57 (0.93–2.66)	0.092
	Recessive	GC-CC	278	283	1.00		106	120	1.00
		GG	80	75	1.09 (0.76–1.55)	0.650	36	23	1.78 (0.99–3.19)	0.054
	Log-additive	-	-	-	1.09 (0.89–1.34)	0.400	-	-	1.47 (1.05–2.07)	0.027
rs11889341	Allele	C	257	236	1.00		98	93	1.00
		T	459	476	1.13 (0.91–1.41)	0.275	186	193	1.09 (0.77–1.55)	0.615
	Genotype	CC	140	157	1.00		58	64	1.00
		TT	39	37	1.18 (0.71–1.96)	0.516	14	14	1.11 (0.49–2.52)	0.810
		TC	179	162	1.24 (0.91–1.69)	0.178	70	65	1.19 (0.73–1.94)	0.489
	Dominant	CC	140	157	1.00		58	64	1.00
		TT-TC	218	199	1.23 (0.91–1.66)	0.176	84	79	1.18 (0.73–1.88)	0.502
	Recessive	TC-CC	319	319	1.00		128	129	1.00
		TT	39	37	1.06 (0.66–1.70)	0.827	14	14	1.01 (0.46–2.21)	0.981
	Log-additive	-	-	-	1.14 (0.91–1.43)	0.261	-	-	1.10 (0.77–1.58)	0.599
rs7574865	Allele	G	252	233	1.00		95	94	1.00
		T	464	483	1.13 (0.90–1.40)	0.289	189	190	1.02 (0.72–1.44)	0.929
	Genotype	GG	142	158	1.00		60	62	1.00
		TT	36	33	1.26 (0.72–2.05)	0.467	13	14	0.96 (0.42–2.23)	0.933
		TG	180	167	1.20 (0.88–1.64)	0.249	69	66	1.08 (0.66–1.77)	0.752
	Dominant	GG	142	158	1.00		60	62	1.00
		TT-TG	216	200	1.20 (0.89–1.62)	0.225	82	80	1.06 (0.66–1.70)	0.802
	Recessive	TG-GG	322	325	1.00		13	14	1.00
		TT	36	33	1.10 (0.67–1.81)	0.704	129	128	0.92 (0.42–2.05)	0.848
	Log-additive	-	-	-	1.14 (0.91–1.43)	0.268	-	-	1.02 (0.71–1.47)	0.916
rs897200	Allele	T	346	350	1.00		141	141	1.00
		C	370	366	0.98 (0.79–1.20)	0.833	143	145	1.01 (0.73–1.41)	0.934
	Genotype	TT	102	91	1.00		35	35	1.00
		CC	90	83	0.97 (0.64–1.46)	0.875	34	33	1.03 (0.53–2.01)	0.930
		CT	166	184	0.80 (0.57–1.14)	0.227	73	75	0.97 (0.55–1.72)	0.927
	Dominant	TT	102	91	1.00		35	35	1.00
		CC-CT	256	267	0.86 (0.61–1.19)	0.354	107	108	0.99 (0.58–1.70)	0.974
	Recessive	CT-TT	268	275	1.00		108	110	1.00
		CC	90	83	1.11 (0.79–1.57)	0.541	34	33	1.05 (0.61–1.81)	0.864
	Log-additive	-	-	-	0.98 (0.80–1.20)	0.833	-	-	1.02 (0.73–1.42)	0.933

CI confidence interval, OR odds ratio
p: values were calculated by unconditional logistic regression analysis with adjustment for age and gender, ^*p < 0.05 indicates statistical significance

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