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Table 4 The SNPs of STAT4 associated with diabetes risk in the subgroup tests

From: Association between STAT4 gene polymorphism and type 2 diabetes risk in Chinese Han population

SNP ID Model genotype Case Control OR (95% CI) p Case Control OR (95% CI) p
Age, years     > 60      ≤ 60    
rs3821236 Allele G 212 232 1.00   267 196 1.00  
   A 268 304 1.04 (0.81–1.33) 0.777 253 270 1.45 (1.13–1.87) 0.004
  Genotype GG 73 90 1.00   61 76 1.00  
   AA 45 54 0.91 (0.54–1.54) 0.729 68 39 2.16 (1.28–3.64) 0.004
   AG 122 124 1.15 (0.76–1.73) 0.507 131 118 1.39 (0.91–2.12) 0.127
  Dominant GG 73 90 1.00   61 76 1.00  
   AA-AG 167 178 1.08 (0.73–1.58) 0.710 199 157 1.58 (1.06–2.35) 0.025
  Recessive AG-GG 195 214 1.00   192 194 1.00  
   AA 45 54 0.84 (0.53–1.33) 0.454 68 39 1.75 (1.12–2.73) 0.014
  Log-additive - - - 0.98 (0.76–1.26) 0.864 - - 1.46 (1.13–1.90) 0.004
rs11893432 Allele C 214 239 1.00   269 203 1.00  
   G 266 297 1.00 (0.78–1.28) 0.998 251 263 1.39 (1.08–1.79) 0.010
  Genotype CC 74 85 1.00   59 72 1.00  
   GG 48 56 0.89 (0.53–1.49) 0.664 68 42 1.97 (1.17–3.32) 0.010
   CG 118 127 1.00 (0.66–1.51) 1.000 133 119 1.39 (0.91–2.13) 0.130
  Dominant CC 74 85 1.00   59 72 1.00  
   GG-GC 166 183 0.97 (0.66–1.43) 0.866 201 161 1.54 (1.03–2.31) 0.036
  Recessive GC-CC 192 212 1.00   192 191 1.00  
   GG 48 56 0.84 (0.53–1.33) 0.454 68 42 1.59 (1.03–2.46) 0.038
  Log-additive - - - 0.95 (0.74–1.23) 0.695 - - 1.40 (1.08–1.82) 0.010
rs11889341 Allele C 158 181 1.00   197 148 1.00  
   T 322 355 0.96 (0.74–1.25) 0.774 323 314 1.29 (0.99–1.69) 0.055
  Genotype CC 107 119 1.00   91 102 1.00  
   TT 25 32 0.87 (0.47–1.60) 0.644 28 19 1.60 (0.83–3.06) 0.161
   TC 108 117 1.01 (0.69–1.48) 0.944 141 110 1.46 (1.00–2.13) 0.052
  Dominant CC 107 119 1.00   91 102 1.00  
   TT-TC 133 149 0.98 (0.68–1.41) 0.925 169 129 1.48 (1.03–2.13) 0.037
  Recessive TC-CC 215 236 1.00   232 212 1.00  
   TT 25 32 0.86 (0.48–1.54) 0.611 28 19 1.29 (0.70–2.39) 0.416
  Log-additive - - - 0.96 (0.73–1.26) 0.757 - - 1.34 (1.01–1.78) 0.046
rs7574865 Allele G 154 173 1.00   193 154 1.00  
   T 326 361 0.99 (0.76–1.28) 0.915 327 312 1.20 (0.92–1.56) 0.182
  Genotype GG 109 121 1.00   93 99 1.00  
   TT 23 27 1.01 (0.54–1.91) 0.972 26 20 1.32 (0.68–2.53) 0.412
   TG 108 119 1.01 (0.69–1.47) 0.967 141 114 1.33 (0.91–1.94) 0.138
  Dominant GG 109 121 1.00   93 99 1.00  
   TT-TG 131 146 1.01 (0.70–1.45) 0.963 167 134 1.33 (0.92–1.91) 0.127
  Recessive TG-GG 217 240 1.00   234 213 1.00  
   TT 23 27 1.01 (0.55–1.85) 0.981 26 20 1.12 (0.60–2.08) 0.722
  Log-additive - - - 1.01 (0.76–1.33) 0.963 - - 1.22 (0.92–1.62) 0.177
rs897200 Allele T 236 265 1.00   245 224 1.00  
   C 244 271 0.99 (0.77–1.27) 0.931 275 242 0.96 (0.75–1.24) 0.765
  Genotype TT 65 69 1.00   75 58 1.00  
   CC 61 66 1.13 (0.68–1.88) 0.626 60 49 0.91 (0.54–1.52) 0.713
   CT 114 133 1.00 (0.64–1.54) 0.990 125 126 0.75 (0.49–1.15) 0.191
  Dominant TT 65 69 1.00   75 58 1.00  
   CC-CT 175 199 1.04 (0.69–1.57) 0.847 185 175 0.80 (0.53–1.19) 0.268
  Recessive CT-TT 179 202 1.00   200 184 1.00  
   CC 61 66 1.14 (0.75–1.72) 0.549 60 49 1.10 (0.71–1.69) 0.677
  Log-additive - - - 1.06 (0.83–1.37) 0.630 - - 0.94 (0.73–1.22) 0.648
SNP ID Model genotype Case Control OR (95% CI) p Case Control OR (95% CI) p
Gender    Male     Female    
rs3821236 Allele G 336 302 1.00   143 126 1.00  
   A 380 414 1.21 (0.98–1.49) 0.071 141 160 1.29 (0.93–1.79) 0.154
  Genotype GG 101 122 1.00   33 44 1.00  
   AA 79 66 1.45 (0.95–2.20) 0.085 34 27 1.69 (0.85–3.33) 0.132
   AG 178 170 1.27 (0.90–1.77) 0.172 75 72 1.39 (0.80–2.40) 0.245
  Dominant GG 101 122 1.00   33 44 1.00  
   AA-AG 257 236 1.32 (0.96–1.81) 0.090 109 99 1.47 (0.87–2.49) 0.153
  Recessive AG-GG 279 292 1.00   108 116 1.00  
   AA 79 66 1.25 (0.87–1.81) 0.227 34 27 1.36 (0.77–2.40) 0.295
  Log-additive - - - 1.21 (0.98–1.49) 0.073 - - 1.30 (0.93–1.83) 0.125-
rs11893432 Allele C 338 322 1.00   145 120 1.00  
   G 378 394 1.09 (0.89–1.35) 0.396 139 166 1.44 (1.04–2.01) 0.029
  Genotype CC 100 111 1.00   33 46 1.00  
   GG 80 75 1.18 (0.78–1.79) 0.425 36 23 2.19 (1.10–4.37) 0.026
   GC 178 172 1.15 (0.82–1.62) 0.427 73 74 1.38 (0.79–2.40) 0.254
  Dominant CC 100 111 1.00   33 46 1.00  
   GG-GC 258 247 1.16 (0.84–1.60) 0.367 109 97 1.57 (0.93–2.66) 0.092
  Recessive GC-CC 278 283 1.00   106 120 1.00  
   GG 80 75 1.09 (0.76–1.55) 0.650 36 23 1.78 (0.99–3.19) 0.054
  Log-additive - - - 1.09 (0.89–1.34) 0.400 - - 1.47 (1.05–2.07) 0.027
rs11889341 Allele C 257 236 1.00   98 93 1.00  
   T 459 476 1.13 (0.91–1.41) 0.275 186 193 1.09 (0.77–1.55) 0.615
  Genotype CC 140 157 1.00   58 64 1.00  
   TT 39 37 1.18 (0.71–1.96) 0.516 14 14 1.11 (0.49–2.52) 0.810
   TC 179 162 1.24 (0.91–1.69) 0.178 70 65 1.19 (0.73–1.94) 0.489
  Dominant CC 140 157 1.00   58 64 1.00  
   TT-TC 218 199 1.23 (0.91–1.66) 0.176 84 79 1.18 (0.73–1.88) 0.502
  Recessive TC-CC 319 319 1.00   128 129 1.00  
   TT 39 37 1.06 (0.66–1.70) 0.827 14 14 1.01 (0.46–2.21) 0.981
  Log-additive - - - 1.14 (0.91–1.43) 0.261 - - 1.10 (0.77–1.58) 0.599
rs7574865 Allele G 252 233 1.00   95 94 1.00  
   T 464 483 1.13 (0.90–1.40) 0.289 189 190 1.02 (0.72–1.44) 0.929
  Genotype GG 142 158 1.00   60 62 1.00  
   TT 36 33 1.26 (0.72–2.05) 0.467 13 14 0.96 (0.42–2.23) 0.933
   TG 180 167 1.20 (0.88–1.64) 0.249 69 66 1.08 (0.66–1.77) 0.752
  Dominant GG 142 158 1.00   60 62 1.00  
   TT-TG 216 200 1.20 (0.89–1.62) 0.225 82 80 1.06 (0.66–1.70) 0.802
  Recessive TG-GG 322 325 1.00   13 14 1.00  
   TT 36 33 1.10 (0.67–1.81) 0.704 129 128 0.92 (0.42–2.05) 0.848
  Log-additive - - - 1.14 (0.91–1.43) 0.268 - - 1.02 (0.71–1.47) 0.916
rs897200 Allele T 346 350 1.00   141 141 1.00  
   C 370 366 0.98 (0.79–1.20) 0.833 143 145 1.01 (0.73–1.41) 0.934
  Genotype TT 102 91 1.00   35 35 1.00  
   CC 90 83 0.97 (0.64–1.46) 0.875 34 33 1.03 (0.53–2.01) 0.930
   CT 166 184 0.80 (0.57–1.14) 0.227 73 75 0.97 (0.55–1.72) 0.927
  Dominant TT 102 91 1.00   35 35 1.00  
   CC-CT 256 267 0.86 (0.61–1.19) 0.354 107 108 0.99 (0.58–1.70) 0.974
  Recessive CT-TT 268 275 1.00   108 110 1.00  
   CC 90 83 1.11 (0.79–1.57) 0.541 34 33 1.05 (0.61–1.81) 0.864
  Log-additive - - - 0.98 (0.80–1.20) 0.833 - - 1.02 (0.73–1.42) 0.933
  1. CI confidence interval, OR odds ratio
  2. p: values were calculated by unconditional logistic regression analysis with adjustment for age and gender, *p < 0.05 indicates statistical significance
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BMC Medical Genomics

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