Table 6 The SNPs of STAT4 associated with T2D risk in the subgroup tests (smoking and drinking status)
From: Association between STAT4 gene polymorphism and type 2 diabetes risk in Chinese Han population
SNP ID | Model | Genotype | Smoking | Drinking | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |||
Yes | No | Yes | No | |||||||
rs3821236 | Allele | A | 1.31(0.93–1.84) | 0.119 | 1.27(0.96–1.67) | 0.092 | 1.29(0.68–2.45) | 0.964 | 1.42(1.07–1.87) | 0.014* |
G | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Genotype | AA | 1.98(0.93–4.2) | 0.076 | 1.53(0.88–2.65) | 0.132 | 1.07(0.48–2.38) | 0.866 | 1.87(1.07–3.27) | 0.027* | |
AG | 1.08(0.62–1.86) | 0.788 | 1.42(0.90–2.22) | 0.129 | 1.14(0.39–2.39) | 0.344 | 1.73(1.12–2.69) | 0.014* | ||
GG | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Dominant | AA-AG | 1.25(0.74–2.11) | 0.396 | 1.45(0.95–2.21) | 0.084 | 1.02(0.45–1.89) | 0.510 | 1.77(1.17–2.68) | 0.006* | |
GG | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Recessive | AA | 1.89(0.97–3.68) | 0.063 | 1.24(0.76–2.00) | 0.388 | 1.30(0.65–2.59) | 0.460 | 1.35(0.82–2.21) | 0.241 | |
AG-GG | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Log-additive | – | 1.34(0.94–1.91) | 0.102 | 1.25(0.95–1.65) | 0.108 | 1.00(0.67–1.48) | 0.990 | 1.42(1.07–1.88) | 0.015* | |
rs11893432 | Allele | G | 1.12(0.80–1.57) | 0.511 | 1.26(0.96–1.66) | 0.097 | 1.28(0.55–2.18) | 0.261 | 1.43(1.09–1.89) | 0.011* |
C | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Genotype | GG | 1.25(0.63–2.51) | 0.525 | 1.63(0.93–2.88) | 0.090 | 1.09(0.33–1.88) | 0.347 | 2.03(1.15–3.61) | 0.015* | |
GC | 1.08(0.62–1.90) | 0.777 | 1.16(0.74–1.83) | 0.510 | 1.16(0.32–2.13) | 0.114 | 1.52(0.98–2.37) | 0.062 | ||
CC | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Dominant | GG-GC | 1.13(0.67–1.92) | 0.649 | 1.29(0.84–1.97) | 0.250 | 1.23(0.35–2.14) | 0.126 | 1.65(1.09–2.51) | 0.019* | |
CC | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Recessive | GG | 1.19(0.66–2.16) | 0.568 | 1.48(0.91–2.42) | 0.115 | 1.05(0.50–1.92) | 0.882 | 1.56(0.94–2.59) | 0.086 | |
GC-CC | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Log-additive | – | 1.12(0.79–1.58) | 0.531 | 1.27(0.96–1.67) | 0.097 | 1.12(0.56–1.99) | 0.289 | 1.44(1.08–1.91) | 0.012* | |
rs11889341 | Allele | T | 1.17(0.82–1.67) | 0.383 | 1.09(0.81–1.45) | 0.581 | 0.98(0.65–1.46) | 0.906 | 1.22(0.91–1.64) | 0.184 |
C | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Genotype | TT | 1.37(0.56–3.36) | 0.486 | 1.13(0.59–2.18) | 0.713 | 1.27(0.49–3.31) | 0.621 | 1.09(0.57–2.08) | 0.802 | |
TC | 1.24(0.75–2.06) | 0.403 | 1.18(0.78–1.79) | 0.429 | 1.07(0.43–1.97) | 0.371 | 1.61(1.06–2.44) | 0.025* | ||
CC | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Dominant | TT-TC | 1.26(0.77–2.06) | 0.354 | 1.17(0.79–1.74) | 0.430 | 1.22(0.48–2.16) | 0.534 | 1.49(1.01–2.21) | 0.036* | |
CC | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Recessive | TT | 1.22(0.52–2.84) | 0.652 | 1.04(0.56–1.93) | 0.905 | 1.47(0.59–3.62) | 0.406 | 0.85(0.46–1.58) | 0.615 | |
TC-CC | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Log-additive | – | 1.20(0.82–1.77) | 0.354 | 1.10(0.82–1.48) | 0.519 | 1.08(0.65–1.89) | 0.935 | 1.22(0.9–1.65) | 0.202 | |
rs7574865 | Allele | T | 1.21(0.84–1.73) | 0.303 | 1.03(0.77–1.38) | 0.832 | 1.06(0.64–2.23) | 0.835 | 1.18(0.88–1.58) | 0.272 |
G | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Genotype | TT | 1.73(0.65–4.61) | 0.275 | 1.07(0.50–1.87) | 0.927 | 1.33(0.47–3.77) | 0.589 | 0.95(0.50–1.82) | 0.883 | |
TG | 1.18(0.71–1.95) | 0.520 | 1.20(0.79–1.81) | 0.390 | 1.05(0.42–2.02) | 0.311 | 1.62(1.07–2.45) | 0.023* | ||
GG | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Dominant | TT-TG | 1.24(0.76–2.02) | 0.387 | 1.15(0.78–1.70) | 0.482 | 1.11(0.47–2.04) | 0.451 | 1.46(0.99–2.16) | 0.058 | |
GG | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Recessive | TT | 1.58(0.61–4.04) | 0.344 | 1.08(0.47–1.95) | 0.697 | 1.56(0.58–4.22) | 0.377 | 0.75(0.40–1.38) | 0.349 | |
TG-GG | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Log-additive | – | 1.25(0.84–1.85) | 0.267 | 1.05(0.78–1.42) | 0.728 | 0.96(0.62–1.48) | 0.843 | 1.17(0.86–1.58) | 0.314 | |
rs897200 | Allele | C | 1.02(0.66–1.89) | 0.641 | 1.23(0.94–1.62) | 0.136 | 0.93(0.63–1.36) | 0.706 | 1.21(0.92–1.60) | 0.165 |
T | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Genotype | CC | 1.04(0.43–2.02) | 0.600 | 1.51(0.86–2.65) | 0.153 | 1.38(0.43–2.03) | 0.737 | 1.62(0.90–2.91) | 0.111 | |
CT | 1.06(0.43–1.86) | 0.358 | 1.20(0.76–1.90) | 0.440 | 1.13(0.59–2.16) | 0.711 | 0.88(0.56–1.39) | 0.578 | ||
TT | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Dominant | CC-CT | 1.19(0.46–2.35) | 0.388 | 1.28(0.83–1.98) | 0.261 | 1.03(0.57–1.87) | 0.924 | 1.04(0.67–1.62) | 0.849 | |
TT | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Recessive | CC | 1.00(0.57–1.92) | 0.973 | 1.34(0.83–2.16) | 0.230 | 1.22(0.44–1.91) | 0.525 | 1.76(1.06–2.91) | 0.028* | |
CT-TT | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Log-additive | – | 1.01(0.66–2.06) | 0.582 | 1.23(0.93–1.62) | 0.154 | 0.94(0.66–1.36) | 0.750 | 1.23(0.93–1.62) | 0.149 | |