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Table 6 The SNPs of STAT4 associated with T2D risk in the subgroup tests (smoking and drinking status)

From: Association between STAT4 gene polymorphism and type 2 diabetes risk in Chinese Han population

SNP ID Model Genotype Smoking Drinking
OR (95% CI) p OR (95% CI) p OR (95% CI) p OR (95% CI) p
Yes No Yes No
rs3821236 Allele A 1.31(0.93–1.84) 0.119 1.27(0.96–1.67) 0.092 1.29(0.68–2.45) 0.964 1.42(1.07–1.87) 0.014*
   G 1.00   1.00   1.00   1.00  
  Genotype AA 1.98(0.93–4.2) 0.076 1.53(0.88–2.65) 0.132 1.07(0.48–2.38) 0.866 1.87(1.07–3.27) 0.027*
   AG 1.08(0.62–1.86) 0.788 1.42(0.90–2.22) 0.129 1.14(0.39–2.39) 0.344 1.73(1.12–2.69) 0.014*
   GG 1.00   1.00   1.00   1.00  
  Dominant AA-AG 1.25(0.74–2.11) 0.396 1.45(0.95–2.21) 0.084 1.02(0.45–1.89) 0.510 1.77(1.17–2.68) 0.006*
   GG 1.00   1.00   1.00   1.00  
  Recessive AA 1.89(0.97–3.68) 0.063 1.24(0.76–2.00) 0.388 1.30(0.65–2.59) 0.460 1.35(0.82–2.21) 0.241
   AG-GG 1.00   1.00   1.00   1.00  
  Log-additive 1.34(0.94–1.91) 0.102 1.25(0.95–1.65) 0.108 1.00(0.67–1.48) 0.990 1.42(1.07–1.88) 0.015*
rs11893432 Allele G 1.12(0.80–1.57) 0.511 1.26(0.96–1.66) 0.097 1.28(0.55–2.18) 0.261 1.43(1.09–1.89) 0.011*
   C 1.00   1.00   1.00   1.00  
  Genotype GG 1.25(0.63–2.51) 0.525 1.63(0.93–2.88) 0.090 1.09(0.33–1.88) 0.347 2.03(1.15–3.61) 0.015*
   GC 1.08(0.62–1.90) 0.777 1.16(0.74–1.83) 0.510 1.16(0.32–2.13) 0.114 1.52(0.98–2.37) 0.062
   CC 1.00   1.00   1.00   1.00  
  Dominant GG-GC 1.13(0.67–1.92) 0.649 1.29(0.84–1.97) 0.250 1.23(0.35–2.14) 0.126 1.65(1.09–2.51) 0.019*
   CC 1.00   1.00   1.00   1.00  
  Recessive GG 1.19(0.66–2.16) 0.568 1.48(0.91–2.42) 0.115 1.05(0.50–1.92) 0.882 1.56(0.94–2.59) 0.086
   GC-CC 1.00   1.00   1.00   1.00  
  Log-additive 1.12(0.79–1.58) 0.531 1.27(0.96–1.67) 0.097 1.12(0.56–1.99) 0.289 1.44(1.08–1.91) 0.012*
rs11889341 Allele T 1.17(0.82–1.67) 0.383 1.09(0.81–1.45) 0.581 0.98(0.65–1.46) 0.906 1.22(0.91–1.64) 0.184
   C 1.00   1.00   1.00   1.00  
  Genotype TT 1.37(0.56–3.36) 0.486 1.13(0.59–2.18) 0.713 1.27(0.49–3.31) 0.621 1.09(0.57–2.08) 0.802
   TC 1.24(0.75–2.06) 0.403 1.18(0.78–1.79) 0.429 1.07(0.43–1.97) 0.371 1.61(1.06–2.44) 0.025*
   CC 1.00   1.00   1.00   1.00  
  Dominant TT-TC 1.26(0.77–2.06) 0.354 1.17(0.79–1.74) 0.430 1.22(0.48–2.16) 0.534 1.49(1.01–2.21) 0.036*
   CC 1.00   1.00   1.00   1.00  
  Recessive TT 1.22(0.52–2.84) 0.652 1.04(0.56–1.93) 0.905 1.47(0.59–3.62) 0.406 0.85(0.46–1.58) 0.615
   TC-CC 1.00   1.00   1.00   1.00  
  Log-additive 1.20(0.82–1.77) 0.354 1.10(0.82–1.48) 0.519 1.08(0.65–1.89) 0.935 1.22(0.9–1.65) 0.202
rs7574865 Allele T 1.21(0.84–1.73) 0.303 1.03(0.77–1.38) 0.832 1.06(0.64–2.23) 0.835 1.18(0.88–1.58) 0.272
   G 1.00   1.00   1.00   1.00  
  Genotype TT 1.73(0.65–4.61) 0.275 1.07(0.50–1.87) 0.927 1.33(0.47–3.77) 0.589 0.95(0.50–1.82) 0.883
   TG 1.18(0.71–1.95) 0.520 1.20(0.79–1.81) 0.390 1.05(0.42–2.02) 0.311 1.62(1.07–2.45) 0.023*
   GG 1.00   1.00   1.00   1.00  
  Dominant TT-TG 1.24(0.76–2.02) 0.387 1.15(0.78–1.70) 0.482 1.11(0.47–2.04) 0.451 1.46(0.99–2.16) 0.058
   GG 1.00   1.00   1.00   1.00  
  Recessive TT 1.58(0.61–4.04) 0.344 1.08(0.47–1.95) 0.697 1.56(0.58–4.22) 0.377 0.75(0.40–1.38) 0.349
   TG-GG 1.00   1.00   1.00   1.00  
  Log-additive 1.25(0.84–1.85) 0.267 1.05(0.78–1.42) 0.728 0.96(0.62–1.48) 0.843 1.17(0.86–1.58) 0.314
rs897200 Allele C 1.02(0.66–1.89) 0.641 1.23(0.94–1.62) 0.136 0.93(0.63–1.36) 0.706 1.21(0.92–1.60) 0.165
   T 1.00   1.00   1.00   1.00  
  Genotype CC 1.04(0.43–2.02) 0.600 1.51(0.86–2.65) 0.153 1.38(0.43–2.03) 0.737 1.62(0.90–2.91) 0.111
   CT 1.06(0.43–1.86) 0.358 1.20(0.76–1.90) 0.440 1.13(0.59–2.16) 0.711 0.88(0.56–1.39) 0.578
   TT 1.00   1.00   1.00   1.00  
  Dominant CC-CT 1.19(0.46–2.35) 0.388 1.28(0.83–1.98) 0.261 1.03(0.57–1.87) 0.924 1.04(0.67–1.62) 0.849
   TT 1.00   1.00   1.00   1.00  
  Recessive CC 1.00(0.57–1.92) 0.973 1.34(0.83–2.16) 0.230 1.22(0.44–1.91) 0.525 1.76(1.06–2.91) 0.028*
   CT-TT 1.00   1.00   1.00   1.00  
  Log-additive 1.01(0.66–2.06) 0.582 1.23(0.93–1.62) 0.154 0.94(0.66–1.36) 0.750 1.23(0.93–1.62) 0.149
  1. CI confidence interval, OR odds ratio
  2. p values were calculated by unconditional logistic regression analysis with adjustment for age and gender; *p < 0.05 indicates statistical significance