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Table 7 Correlation between STAT4 gene polymorphism and the occurrence of diabetes complications

From: Association between STAT4 gene polymorphism and type 2 diabetes risk in Chinese Han population

SNP ID Model Genotype T2D complicated with nephropathy T2D complicated with CHD
DN No DN OR (95% CI) p Case Control OR (95% CI) p
rs3821236 Allele A 127 352 0.78(0.59–1.02) 0.073 127 352 1.14(0.86–1.52) 0.359
   G 165 356 1.00   125 396 1.00  
  Genotype AA 30 83 0.65(0.37–1.14) 0.131 30 83 1.41(0.77–2.60) 0.266
   AG 67 186 0.62(0.40–0.99) 0.024* 67 186 1.35(0.81–2.25) 0.251
   GG 49 85 1.00   29 105 1.00  
  Dominant AA-AG 97 269 0.63(0.41–0.97) 0.037* 97 269 1.37(0.84–2.23) 0.207
   GG 49 85 1.00   29 105 1.00  
  Recessive AA 30 83 0.88(0.54–1.42) 0.589 30 83 1.16(0.70–1.91) 0.567
   AG-GG 116 271 1.00   96 291 1.00  
  Log-additive 0.79(0.59–1.05) 0.099 1.19(0.88–1.61) 0.252
rs11893432 Allele G 131 352 0.82(0.63–1.08) 0.163 126 357 1.10(0.82–1.46) 0.532
   C 161 356 1.00   126 391 1.00  
  Genotype GG 30 86 0.71(0.40–1.24) 0.227 30 86 1.29(0.70–2.35) 0.416
   GC 71 180 0.78(0.49–1.23) 0.280 66 185 1.26(0.76–2.10) 0.371
   CC 45 88 1.00   30 103 1.00  
  Dominant GG-GC 101 266 0.75(0.49–1.17) 0.203 96 271 1.27(0.78–2.06) 0.334
   CC 45 88 1.00   30 103 1.00  
  Recessive GG 30 86 0.83(0.51–1.35) 0.455 30 86 1.10(0.67–1.81) 0.704
   GC-CC 116 268 1.00   96 288 1.00  
  Log-additive 0.84(0.63–1.11) 0.212 1.14(0.84–1.53) 0.402
rs11889341 Allele T 97 258 0.87(0.65–1.16) 0.333 81 274 0.82(0.61–1.11) 0.198
   C 195 450 1.00   171 474 1.00  
  Genotype TT 15 38 0.81(0.41–1.62) 0.558 10 43 0.56(0.25–1.25) 0.156
   TC 67 182 0.79(0.52–1.21) 0.280 61 188 0.89(0.57–1.37) 0.589
   CC 64 134 1.00   55 143 1.00  
  Dominant TT-TC 82 220 0.80(0.54–1.19) 0.268 71 231 0.82(0.54–1.26) 0.370
   CC 64 134 1.00   55 143 1.00  
  Recessive TT 15 38 0.92(0.48–1.77) 0.807 10 43 0.60(0.28–1.28) 0.188
   TC-CC 131 316 1.00   116 331 1.00  
  Log-additive 0.86(0.63–1.17) 0.339 0.80(0.58–1.12) 0.192
rs7574865 Allele T 96 251 0.89(0.67–1.19) 0.437 82 265 0.88(0.65–1.19) 0.405
   G 196 457 1.00   170 483 1.00  
  Genotype TT 14 35 0.90(0.45–1.83) 0.775 9 40 0.65(0.29–1.47) 0.302
   TG 68 181 0.84(0.55–1.27) 0.410 64 185 1.04(0.67–1.61) 0.869
   GG 64 138 1.00   53 149 1.00  
  Dominant TT-TG 82 216 0.85(0.57–1.27) 0.423 73 225 0.97(0.63–1.48) 0.882
   GG 64 138 1.00   53 149 1.00  
  Recessive TT 14 35 0.99(0.51–1.94) 0.980 9 40 0.64(0.29–1.39) 0.259
   TG-GG 132 319 1.00   117 334 1.00  
  Log-additive 0.91(0.66–1.24) 0.530 0.90(0.65–1.25) 0.524
rs897200 Allele C 147 342 1.09(0.83–1.43) 0.558 129 360 1.13(0.85–1.5) 0.400
   T 145 366 1.00   123 388 1.00  
  Genotype CC 35 90 1.10(0.63–1.93) 0.741 35 90 1.16(0.65–2.07) 0.605
   CT 77 162 1.44(0.89–2.33) 0.139 59 180 1.05(0.63–1.75) 0.852
   TT 34 102 1.00   32 104 1.00  
  Dominant CC-CT 112 252 1.32(0.83–2.07) 0.239 94 270 1.09(0.68–1.75) 0.725
   TT 34 102 1.00   32 104 1.00  
  Recessive CC 35 90 0.87(0.55–1.38) 0.545 35 90 1.13(0.70–1.82) 0.617
   CT-TT 111 264 1.00   91 284 1.00  
  Log-additive 1.05(0.80–1.38) 0.717 1.08(0.81–1.44) 0.606
  1. CHD coronary heart disease, CI confidence interval, OR odds ratio
  2. p values were calculated by unconditional logistic regression analysis with adjustment for age and gender; *p < 0.05 indicates statistical significance