Table 7 Correlation between STAT4 gene polymorphism and the occurrence of diabetes complications
From: Association between STAT4 gene polymorphism and type 2 diabetes risk in Chinese Han population
SNP ID | Model | Genotype | T2D complicated with nephropathy | T2D complicated with CHD | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
DN | No DN | OR (95% CI) | p | Case | Control | OR (95% CI) | p | |||
rs3821236 | Allele | A | 127 | 352 | 0.78(0.59–1.02) | 0.073 | 127 | 352 | 1.14(0.86–1.52) | 0.359 |
G | 165 | 356 | 1.00 | 125 | 396 | 1.00 | ||||
Genotype | AA | 30 | 83 | 0.65(0.37–1.14) | 0.131 | 30 | 83 | 1.41(0.77–2.60) | 0.266 | |
AG | 67 | 186 | 0.62(0.40–0.99) | 0.024* | 67 | 186 | 1.35(0.81–2.25) | 0.251 | ||
GG | 49 | 85 | 1.00 | 29 | 105 | 1.00 | ||||
Dominant | AA-AG | 97 | 269 | 0.63(0.41–0.97) | 0.037* | 97 | 269 | 1.37(0.84–2.23) | 0.207 | |
GG | 49 | 85 | 1.00 | 29 | 105 | 1.00 | ||||
Recessive | AA | 30 | 83 | 0.88(0.54–1.42) | 0.589 | 30 | 83 | 1.16(0.70–1.91) | 0.567 | |
AG-GG | 116 | 271 | 1.00 | 96 | 291 | 1.00 | ||||
Log-additive | – | – | – | 0.79(0.59–1.05) | 0.099 | – | – | 1.19(0.88–1.61) | 0.252 | |
rs11893432 | Allele | G | 131 | 352 | 0.82(0.63–1.08) | 0.163 | 126 | 357 | 1.10(0.82–1.46) | 0.532 |
C | 161 | 356 | 1.00 | 126 | 391 | 1.00 | ||||
Genotype | GG | 30 | 86 | 0.71(0.40–1.24) | 0.227 | 30 | 86 | 1.29(0.70–2.35) | 0.416 | |
GC | 71 | 180 | 0.78(0.49–1.23) | 0.280 | 66 | 185 | 1.26(0.76–2.10) | 0.371 | ||
CC | 45 | 88 | 1.00 | 30 | 103 | 1.00 | ||||
Dominant | GG-GC | 101 | 266 | 0.75(0.49–1.17) | 0.203 | 96 | 271 | 1.27(0.78–2.06) | 0.334 | |
CC | 45 | 88 | 1.00 | 30 | 103 | 1.00 | ||||
Recessive | GG | 30 | 86 | 0.83(0.51–1.35) | 0.455 | 30 | 86 | 1.10(0.67–1.81) | 0.704 | |
GC-CC | 116 | 268 | 1.00 | 96 | 288 | 1.00 | ||||
Log-additive | – | – | – | 0.84(0.63–1.11) | 0.212 | – | – | 1.14(0.84–1.53) | 0.402 | |
rs11889341 | Allele | T | 97 | 258 | 0.87(0.65–1.16) | 0.333 | 81 | 274 | 0.82(0.61–1.11) | 0.198 |
C | 195 | 450 | 1.00 | 171 | 474 | 1.00 | ||||
Genotype | TT | 15 | 38 | 0.81(0.41–1.62) | 0.558 | 10 | 43 | 0.56(0.25–1.25) | 0.156 | |
TC | 67 | 182 | 0.79(0.52–1.21) | 0.280 | 61 | 188 | 0.89(0.57–1.37) | 0.589 | ||
CC | 64 | 134 | 1.00 | 55 | 143 | 1.00 | ||||
Dominant | TT-TC | 82 | 220 | 0.80(0.54–1.19) | 0.268 | 71 | 231 | 0.82(0.54–1.26) | 0.370 | |
CC | 64 | 134 | 1.00 | 55 | 143 | 1.00 | ||||
Recessive | TT | 15 | 38 | 0.92(0.48–1.77) | 0.807 | 10 | 43 | 0.60(0.28–1.28) | 0.188 | |
TC-CC | 131 | 316 | 1.00 | 116 | 331 | 1.00 | ||||
Log-additive | – | – | – | 0.86(0.63–1.17) | 0.339 | – | – | 0.80(0.58–1.12) | 0.192 | |
rs7574865 | Allele | T | 96 | 251 | 0.89(0.67–1.19) | 0.437 | 82 | 265 | 0.88(0.65–1.19) | 0.405 |
G | 196 | 457 | 1.00 | 170 | 483 | 1.00 | ||||
Genotype | TT | 14 | 35 | 0.90(0.45–1.83) | 0.775 | 9 | 40 | 0.65(0.29–1.47) | 0.302 | |
TG | 68 | 181 | 0.84(0.55–1.27) | 0.410 | 64 | 185 | 1.04(0.67–1.61) | 0.869 | ||
GG | 64 | 138 | 1.00 | 53 | 149 | 1.00 | ||||
Dominant | TT-TG | 82 | 216 | 0.85(0.57–1.27) | 0.423 | 73 | 225 | 0.97(0.63–1.48) | 0.882 | |
GG | 64 | 138 | 1.00 | 53 | 149 | 1.00 | ||||
Recessive | TT | 14 | 35 | 0.99(0.51–1.94) | 0.980 | 9 | 40 | 0.64(0.29–1.39) | 0.259 | |
TG-GG | 132 | 319 | 1.00 | 117 | 334 | 1.00 | ||||
Log-additive | – | – | – | 0.91(0.66–1.24) | 0.530 | – | – | 0.90(0.65–1.25) | 0.524 | |
rs897200 | Allele | C | 147 | 342 | 1.09(0.83–1.43) | 0.558 | 129 | 360 | 1.13(0.85–1.5) | 0.400 |
T | 145 | 366 | 1.00 | 123 | 388 | 1.00 | ||||
Genotype | CC | 35 | 90 | 1.10(0.63–1.93) | 0.741 | 35 | 90 | 1.16(0.65–2.07) | 0.605 | |
CT | 77 | 162 | 1.44(0.89–2.33) | 0.139 | 59 | 180 | 1.05(0.63–1.75) | 0.852 | ||
TT | 34 | 102 | 1.00 | 32 | 104 | 1.00 | ||||
Dominant | CC-CT | 112 | 252 | 1.32(0.83–2.07) | 0.239 | 94 | 270 | 1.09(0.68–1.75) | 0.725 | |
TT | 34 | 102 | 1.00 | 32 | 104 | 1.00 | ||||
Recessive | CC | 35 | 90 | 0.87(0.55–1.38) | 0.545 | 35 | 90 | 1.13(0.70–1.82) | 0.617 | |
CT-TT | 111 | 264 | 1.00 | 91 | 284 | 1.00 | ||||
Log-additive | – | – | – | 1.05(0.80–1.38) | 0.717 | – | – | 1.08(0.81–1.44) | 0.606 | |