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Fig. 4 | BMC Medical Genomics

Fig. 4

From: Repeat to gene expression ratios in leukemic blast cells can stratify risk prediction in acute myeloid leukemia

Fig. 4

IPA analysis in AML patient subgroups with high or low R/G ratios. a Ingenuity pathway analysis (IPA) performed in High-repeat (n = 16) versus Mid-repeat (n = 89) and in Low-repeat (n = 15) versus Mid-repeat (n = 89) AML patient samples. As inputs for the IPA, the log2FoldChange values from the differential gene expression analysis were used, after filtering for a minimum expression (baseMean expression > 100 normalized reads), fold-change (absolute value of log2FoldChange > 1), and significance (adjusted p-value < 0.05). z-score values are indicated by color code, where purple represents down-regulation and orange up-regulation of a pathway. The numbers specify the number of genes that are dysregulated in each of the different pathways. b Example for specific genes that are dysregulated in High-repeat (High) versus Mid-repeat (Mid) (MYC, ABL1, PELI1, SNX13) or in Low-repeat (Low) versus Mid-repeat (Mid) (PDGFR, TRANSFERRIN) AML patient samples. Shown are normalized read counts for gene specific transcripts. Statistical significance is indicated by adjusted p-values

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