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Fig. 5 | BMC Medical Genomics

Fig. 5

From: Repeat to gene expression ratios in leukemic blast cells can stratify risk prediction in acute myeloid leukemia

Fig. 5

Survival probability and Cox hazard risks in AML patient subgroups with high or low R/G ratios. a Kaplan–Meier univariate survival analysis was performed on AML patient samples using metadata available from the TCGA study. Kaplan–Meier univariate survival analysis found the High-repeat TCGA AML patients (n = 27) had a higher overall survival probability as compared to the Low-repeat TCGA AML patients (n = 31) (p-value of 0.0039). b Cox proportional hazards multivariate analysis was performed on AML patient samples using metadata available from the TCGA study by comparing age, gender, cytogenetic risk category (favorable, intermediate and adverse), AML subtypes and R/G ratios. All p-values < 0.05 are considered significant. A hazard ratio above 1 (dashed line) indicates an increased risk for an event (relapse, progression, death), while a hazard ratio below 1 indicates a reduced risk. R/G ratios significantly segregate from age and cytogenetic risk categories with a hazard index of 0.00016 (95% confidence interval: 4.2e − 07–0.06; p-value of 0.004)

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