|
Parameters
|
CC(n = 26)
|
CG(n = 26) + GG(n = 8)
|
P value
|
|---|
|
N (male/female)
|
26 (16/10)
|
34(20/14)
|
0.902Δ
|
|
FPG (mmol/L)
|
|
Before
|
10.73 ± 2.05
|
10.81 ± 1.92
|
0.877
|
|
After
|
6.98 ± 1.35
|
7.94 ± 1.23
|
0.006*
|
|
DV
|
− 3.75 ± 1.68
|
− 2.87 ± 1.32
|
0.027*
|
|
PPG (mmol/L)
|
|
Before
|
14.51 ± 4.31
|
13.04 ± 4.72
|
0.220
|
|
After
|
9.34 ± 3.24
|
9.27 ± 3.49
|
0.937
|
|
DV
|
− 5.17 ± 4.08
|
− 3.77 ± 3.19
|
0.141#
|
|
FINS (mU/L)
|
|
Before
|
8.82 ± 6.81
|
7.80 ± 4.20
|
0.478
|
|
After
|
10.18 ± 6.60
|
9.32 ± 3.64
|
0.522
|
|
DV
|
1.36 ± 4.10
|
1.84 ± 3.80
|
0.641
|
|
PINS (mU/L)
|
|
Before
|
31.42 ± 20.47
|
27.47 ± 16.43
|
0.410
|
|
After
|
48.41 ± 19.78
|
37.13 ± 20.87
|
0.038*
|
|
DV
|
16.99 ± 17.82
|
9.66 ± 19.37
|
0.138
|
|
HOMA-IR
|
|
Before
|
4.48 ± 2.88
|
3.24 ± 1.73
|
0.066
|
|
After
|
3.39 ± 2.12
|
2.43 ± 1.18
|
0.072
|
|
DV
|
− 0.89 ± 1.93
|
− 0.79 ± 1.31
|
0.704
|
|
HOMA-β
|
|
Before
|
27.75 ± 16.03
|
24.08 ± 17.32
|
0.405
|
|
After
|
68.62 ± 45.21
|
49.21 ± 24.36
|
0.037*
|
|
DV
|
40.87 ± 23.52
|
25.13 ± 19.21
|
0.006*
|
|
HbA1c (%)
|
|
Before
|
9.79 ± 1.86
|
9.15 ± 2.26
|
0.246#
|
|
After
|
7.00 ± 0.84
|
7.01 ± 1.05
|
0.968
|
|
DV
|
− 2.79 ± 1.53
|
− 2.14 ± 1.74
|
0.137
|
|
TG (mmol/L)
|
|
Before
|
2.46 ± 1.96
|
2.31 ± 1.90
|
0.766
|
|
After
|
2.21 ± 1.91
|
1.79 ± 1.23
|
0.306
|
|
DV
|
− 0.25 ± 1.95
|
− 0.52 ± 1.58
|
0.096#
|
|
TC (mmol/L)
|
|
Before
|
5.27 ± 1.69
|
5.22 ± 1.15
|
0.892#
|
|
After
|
4.84 ± 1.12
|
4.89 ± 1.37
|
0.880#
|
|
DV
|
− 0.43 ± 1.53
|
− 0.33 ± 1.09
|
0.769#
|
|
HDL-c (mmol/L)
|
|
Before
|
1.42 ± 0.51
|
1.47 ± 0.47
|
0.695#
|
|
After
|
1.35 ± 0.55
|
1.43 ± 0.51
|
0.563#
|
|
DV
|
− 0.07 ± 0.68
|
− 0.04 ± 0.46
|
0.839
|
|
LDL-c (mmol/L)
|
|
Before
|
3.28 ± 1.19
|
3.18 ± 1.05
|
0.731#
|
|
After
|
3.19 ± 1.20
|
3.11 ± 1.07
|
0.786
|
|
DV
|
− 0.09 ± 1.26
|
− 0.07 ± 1.08
|
0.948
|
- BMI body mass index, WHR waist to hip ratio, FPG fasting plasma glucose, PPG postprandial plasma glucose, FINS fasting serum insulin, PINS postprandial serum insulin, HOMA-IR homeostasis model assessment for insulin resistance, HOMA-β Homeostasis model assessment for islet β cell function, HbA1c hemoglobin A1c, TG triglyceride, TC total cholesterol, HDL-c high-density lipoprotein-cholesterol, LDL-c low-density lipoprotein-cholesterol, DV differential values (post-administration minus pre-administration)
- Data are given as (mean ± SD). ΔP values are determined by the Pearson chi-square test. #P values are determined by the Kruskal–Wallis test. *P < 0.05
