Fig. 2

Genetic network underlying baseline refractive eye development controls diverse biological functions and signaling pathways. a Expression of 2,050 genes (q-value < 0.01) is influenced by genetic background and correlates with baseline refractive errors. Hierarchical clustering shows that differential genes are organized in two clusters: one (top) cluster exhibits increased expression in the myopic mice, and the second (bottom) cluster shows increased expression in the hyperopic mice. b Top 30 biological processes affected by the genes involved in baseline refractive eye development. Outer circle of the hierarchical clustering diagram shows hierarchical clusters of biological processes (identified by different colors); inner circle shows clusters of the associated genes up- or down-regulated in hyperopic mice versus myopic mice. c Top 30 canonical pathways affected by the genes associated with baseline refractive eye development. Horizontal yellow line indicates p = 0.05. Z-scores show activation or suppression of the corresponding pathways in animals with hyperopia versus animals with myopia