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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Genome-wide analysis of retinal transcriptome reveals common genetic network underlying perception of contrast and optical defocus detection

Fig. 3

Genetic network subserving susceptibility to form-deprivation myopia controls diverse biological functions and signaling pathways. a Expression of 1347 genes (q-value < 0.01) is influenced by genetic background and correlates with susceptibility to form-deprivation myopia. Hierarchical clustering shows that differential genes are organized in two clusters: one (top) cluster exhibits increased expression in mice with low susceptibility to myopia, and the second (bottom) cluster shows increased expression in mice with high susceptibility to myopia. b Top 30 biological processes affected by the genes involved in optical defocus detection and the development of form-deprivation myopia. Outer circle of the hierarchical clustering diagram shows hierarchical clusters of biological processes (identified by different colors); inner circle shows clusters of the associated genes up- or down-regulated in mice with high susceptibility to myopia versus mice with low susceptibility to myopia. c Top 30 canonical pathways affected by the genes associated with optical defocus detection and the development of form-deprivation myopia. Horizontal yellow line indicates p = 0.05. Z-scores show activation or suppression of the corresponding pathways in animals with high susceptibility to form-deprivation myopia versus animals with low susceptibility to form-deprivation myopia

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