Skip to main content
Fig. 4 | BMC Medical Genomics

Fig. 4

From: Genome-wide analysis of retinal transcriptome reveals common genetic network underlying perception of contrast and optical defocus detection

Fig. 4

Genetic network underlying perception of contrast controls diverse biological functions and signaling pathways. a Expression of 1,024 genes (q-value < 0.01) is influenced by genetic background and correlates with sensitivity to contrast. Hierarchical clustering shows that differential genes are organized in two clusters: one (top) cluster exhibits increased expression in mice with high contrast sensitivity, and the second (bottom) cluster shows increased expression in mice with low contrast sensitivity. b Top 30 biological processes affected by the genes involved in contrast perception. Outer circle of the hierarchical clustering diagram shows hierarchical clusters of biological processes (identified by different colors); inner circle shows clusters of the associated genes up- or down-regulated in mice with high contrast sensitivity versus mice with low contrast sensitivity. c Top 30 canonical pathways affected by the genes associated with contrast perception. Horizontal yellow line indicates p = 0.05. Z-scores show activation or suppression of the corresponding pathways in animals with high contrast sensitivity versus animals with low contrast sensitivity

Back to article page