Fig. 5

Genetic network underlying contrast perception has limited contribution to baseline refractive eye development. a Venn diagram showing overlap between genes underlying contrast sensitivity and genes regulating baseline refractive development. b Top 11 biological processes affected by the genes associated with both contrast perception (top panel) and baseline refractive development in mice (bottom panel). Outer circle shows gene ontology IDs for the biological processes; middle circle shows up- or down-regulated genes in animals with high contrast sensitivity versus animals with low contrast sensitivity (top panel), or in mice with hyperopia versus mice with myopia (bottom panel); inner circle shows activation or suppression of the corresponding biological processes, while the size of the sector corresponds to statistical significance (larger sectors correspond to smaller p-values). c Comparison of canonical signaling pathways involved in contrast perception and baseline refractive eye development. Vertical red line indicates p = 0.05. Vertical grey line indicates p = 0.1. Colors identify pathways associated with either contrast perception or baseline refractive development and correspond to the colors in the Venn diagrams (a)