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Fig. 2 | BMC Medical Genomics

Fig. 2

From: Epigenetic landscapes of intracranial aneurysm risk haplotypes implicate enhancer function of endothelial cells and fibroblasts in dysregulated gene expression

Fig. 2

Visualization of the topologically associated domain (TAD) of four example SNPs in HUVECs. Haplotype outlined in red. TAD outlined in black. Genes reported as differentially expressed in IA tissue studies are highlighted in red (increased expression) or green (decreased expression). Border indicates identified in IA vs control; fill indicates identified in ruptured vs unruptured IAs. A HiC data surrounding rs1429412 shows a large TAD in HUVECs. B Data from HiC analysis shows another large TAD surrounding rs1800796. C HiC data shows the TAD surrounding rs10757278. D HiC map showing TAD encompassing rs6538595 does not contain any genes found to be differentially expressed in IA tissue studies

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BMC Medical Genomics

ISSN: 1755-8794

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