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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Epigenetic landscapes of intracranial aneurysm risk haplotypes implicate enhancer function of endothelial cells and fibroblasts in dysregulated gene expression

Fig. 3

Top IPA networks of transcripts in TADs encompassing predicted enhancers in HUVECs and fibroblasts. Transcripts present in TADs are in grey and lines indicate interactions (solid = direct, dashed = indirect). Genes reported as differentially expressed in IA tissue studies are highlighted in red (increased expression) or green (decreased expression). Border indicates identified in IA vs control; fill indicates identified in ruptured vs unruptured IAs. A For HUVECs, the top network with a p-score of 33 showed hubs at CDKN2A/B, ERK1/2, and collagens. B In fibroblasts, the top network with a p-score  of 27 demonstrated interactions at IL6 and NF-kB

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BMC Medical Genomics

ISSN: 1755-8794

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