Fig. 2
From: New familial cases of karyomegalic interstitial nephritis with mutations in the FAN1 gene
Renal histology in Patient IV-7 and Patient IV-12 in family A. a Renal biopsy, Masson’s trichroma (magnification × 400). Proximal tubules with giant nuclei, irregular nuclear membrane (Patient IV-7). b Renal biopsy, hematoxylin and eosine stain (magnification × 200). Giant nuclei with irregular nuclear membrane (Patient IV-7). c, d Renal biopsy, electron microscopy. Giant karyomegalic nuclei with irregular nuclear membrane (Patient IV-7). e Renal biopsy, electron microscopy. Giant karyomegalic nuclei of epithelial cells of proximal tubules (Patient IV-12)