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Table 1 Clinical and biological findings of patients with KIN in families A and Z

From: New familial cases of karyomegalic interstitial nephritis with mutations in the FAN1 gene

  Patient No Sexe AN AERSD Smoking Personal history Cause of renal examination HMG TR Death Initial creatinine (µmol/l) eGFR ml/min/1.73m2 Cytolisis Cholestasis VST KB Liver Biopsy
Family A IV-2 M 36 36 No 0 Convulsion 0 Yes No 900 9.9 Yes Yes No No
  IV-7 M 39 43 Yes Appendectomy Donor check up 0 Yes Yes 161 69.4 No Yes Yes
K + 
Yes
K-
  IV-11 M 26 29 No 0 Donor Check up 0 No Yes 197 53.38 Yes Yes No No
  IV-12 M 32 38 No Urethritis Donor Check up 0 No No 141 65.9 Yes Yes Yes
K + 
No
Family Z II-2 M 31 36 No 0 Fortuitously 0 Yes Yes 1000 ND No No No No
  II-3 M 25 33 No Epilepsy and visceral leishmaniasis Donor check up 0 No No 200 ND No No Yes
K + 
Yes
K-
  1. AN, age at the time of the discovery of nephropathy; AERSD, Age at the time of the end of renal stage disease; HMG, hepatomegaly; TR, transplantation; eGFR, estimated glomerular filtration rate; VST, viral serology test; KB, Kidney biopsy; K, Karyomegaly; + , present; -, absent; ND, no data