Fig. 4

Differential expression patterns of module eigengenes across CLL patient samples. A Select ME boxplots and non-parametric ANOVA p for relapse status also segregated by CLL stage. B Clustering of MEs (rows) and samples (narrow columns) reveal a sample group (C4) that is enriched > 80% for relapsed individuals, and on average, has elevated expression of the yellow and brown module eigengenes, but downregulated expression of turquoise and blue module eigengenes. The opposite is apparent for the right cluster(C5) of case samples which have < 20% relapsed cases (13/47). The kME table hubs for these 4 modules confirms that these 2 sets of modules have the strongest correlation and anti-correlation in their pattern of expression across all 201 case-samples in the network. Color scale: eigengene expression Z-score