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Fig. 1 | BMC Medical Genomics

Fig. 1

From: Genetic aetiology of primary adrenal insufficiency in Chinese children

Fig. 1

Differences in relevant serum hormones in CAH patients. The data are expressed as the medians (IQRs) due to non-normal distributions. Comparisons between groups were performed using the Mann–Whitney U test. The 17-OHP level and the serum TES level were significantly higher in SW patients than in SV patients [a1: SW 127.93 ng/ml (141.08 ng/ml), n = 38; SV 96.21 ng/ml (78.00 ng/ml), n = 18; p = 0.018. a2: SW 228.90 ng/dl (376.90 ng/dl), n = 38; SV 131.64 ng/dl (125.51 ng/dl), n = 16; p = 0.034]. In SW patients, females had significantly higher serum 17-OHP levels [b1: female 215.36 ng/ml (265.48 ng/ml), n = 16; male 101.93 ng/ml (84.81 ng/ml), n = 22; p = 0.003] and cortisol levels [b2: female 12.88 µg/dl (10.05 µg/dl), n = 16; male 6.88 µg/dl (9.27 µg/dl) n = 22; p = 0.033]. In female children, the SW group had increased 17-OHP [c1: SW 215.36 ng/ml (265.48 ng/ml), n = 16; SV 113.63 ng/ml (83.39 ng/ml), n = 13; p = 0.004], cortisol [c2: SW 12.88 µg/dl (10.05 µg/dl), n = 16; SV 7.35 µg/dl (2.37 µg/dl), n = 10; p = 0.005], TES [c3: SW 325.40 ng/dl (415.44 ng/dl), n = 16; SV 138.27 ng/dl (122.43 ng/dl), n = 11; p = 0.008] and DHEAS [c4: SW 187.45 µg/dl (248.88 µg/dl), n = 14; SV 81.35 µg/dl (133.63 µg/dl), n = 10; p = 0.042] levels. The initial serum levels of 17-OHP in one SW male patient, cortisol in three SV female patients, TES in one SW male patient and two SV female patients, and DHEAS in two SW female patients and three SV female patients were not included due to inconsistent testing methods. Hormone normal ranges ACTH < 46 pg/ml, cortisol 5–25 µg/dl, 17-OHP1 month-1 year 1.06–40.41 ng/ml, 1 year-13 years 0.07–1.53 ng/ml, TES female 0–31 ng/dl, male 0–6 years 3–32 ng/dl, 7–12 years 3–68 ng/dl, DHEAS 35–430 µg/dl

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