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Table 1 Candidate key TFs for up- and down-regulated DEGs

From: RNA-seq analysis reveals significant transcriptome changes in huntingtin-null human neuroblastoma cells

#

Key TF

Description

# Of overlapped genes

P value

FDR

1

REST

RE1-silencing transcription factor

6

1.39e−05

0.000361

2

MYB

v-myb myeloblastosis viral oncogene homolog (avian)

4

0.00341

0.0443

3

POU5F1

POU class 5 homeobox 1

3

0.00744

0.0485

4

FOXF2

Forkhead box F2

2

0.00746

0.0485

5

HOXB7

Homeobox B7

2

0.0117

0.061

6

KLF5

Kruppel-like factor 5 (intestinal)

2

0.0197

0.0852

7

FOXO1

Forkhead box O1

2

0.0616

0.185

8

EGR1

Early growth response 1

4

0.062

0.185

9

PARP1

Poly (ADP-ribose) polymerase 1

2

0.0662

0.185

10

RARA

Retinoic acid receptor, alpha

2

0.071

0.185

11

RUNX3

Runt-related transcription factor 3

2

0.091

0.208

12

DNMT1

DNA (cytosine-5-)-methyltransferase 1

2

0.0962

0.208

13

JUN

Jun proto-oncogene

5

0.109

0.218

14

PPARA

Peroxisome proliferator-activated receptor alpha

2

0.141

0.247

15

NFKB1

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

8

0.143

0.247

16

HIF1A

Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

3

0.166

0.269

17

SP1

Sp1 transcription factor

11

0.177

0.271

18

CEBPA

CCAAT/enhancer binding protein (C/EBP), alpha

2

0.213

0.308

19

WT1

Wilms tumor 1

2

0.251

0.343

20

SPI1

Spleen focus forming virus (SFFV) proviral integration oncogene spi1

2

0.282

0.367

21

USF1

Upstream transcription factor 1

2

0.301

0.373

22

RELA

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

6

0.399

0.471

23

STAT1

Signal transducer and activator of transcription 1, 91 kDa

2

0.417

0.471

24

CREB1

cAMP responsive element binding protein 1

2

0.451

0.475

25

YY1

YY1 transcription factor

2

0.457

0.475

26

TP53

Tumor protein p53

3

0.526

0.526