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Table 1 Candidate key TFs for up- and down-regulated DEGs

From: RNA-seq analysis reveals significant transcriptome changes in huntingtin-null human neuroblastoma cells

# Key TF Description # Of overlapped genes P value FDR
1 REST RE1-silencing transcription factor 6 1.39e−05 0.000361
2 MYB v-myb myeloblastosis viral oncogene homolog (avian) 4 0.00341 0.0443
3 POU5F1 POU class 5 homeobox 1 3 0.00744 0.0485
4 FOXF2 Forkhead box F2 2 0.00746 0.0485
5 HOXB7 Homeobox B7 2 0.0117 0.061
6 KLF5 Kruppel-like factor 5 (intestinal) 2 0.0197 0.0852
7 FOXO1 Forkhead box O1 2 0.0616 0.185
8 EGR1 Early growth response 1 4 0.062 0.185
9 PARP1 Poly (ADP-ribose) polymerase 1 2 0.0662 0.185
10 RARA Retinoic acid receptor, alpha 2 0.071 0.185
11 RUNX3 Runt-related transcription factor 3 2 0.091 0.208
12 DNMT1 DNA (cytosine-5-)-methyltransferase 1 2 0.0962 0.208
13 JUN Jun proto-oncogene 5 0.109 0.218
14 PPARA Peroxisome proliferator-activated receptor alpha 2 0.141 0.247
15 NFKB1 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 8 0.143 0.247
16 HIF1A Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 3 0.166 0.269
17 SP1 Sp1 transcription factor 11 0.177 0.271
18 CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 2 0.213 0.308
19 WT1 Wilms tumor 1 2 0.251 0.343
20 SPI1 Spleen focus forming virus (SFFV) proviral integration oncogene spi1 2 0.282 0.367
21 USF1 Upstream transcription factor 1 2 0.301 0.373
22 RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 6 0.399 0.471
23 STAT1 Signal transducer and activator of transcription 1, 91 kDa 2 0.417 0.471
24 CREB1 cAMP responsive element binding protein 1 2 0.451 0.475
25 YY1 YY1 transcription factor 2 0.457 0.475
26 TP53 Tumor protein p53 3 0.526 0.526