Skip to main content
Fig. 1 | BMC Medical Genomics

Fig. 1

From: DMD/BMD prenatal diagnosis and treatment expectation in a single centre in China for 15 years

Fig. 1

DMD gene recombination observed by STR linkage analysis. a The proband (II3) had the mutation c.8854C > T. The mother (I2) was a carrier. The same mutation was detected in the female fetus (II4) by Sanger sequencing. Linkage analysis showed that the fetus inherited the same high-risk haplotype as the affected proband at the following STR markers: STR44/STR45/STR49/STR50/3′MP1P, but the opposite allele at STR07 indicated that the fetus inherited a recombinant DMD gene. b The proband (II3) had the mutation c.1831G > T. The mother (I2) was a carrier. The same mutation cannot be detected in the male fetus (II4) by Sanger sequencing. Linkage analysis showed that the fetus inherited the same high-risk haplotype as the affected proband at the following STR markers: STR44/STR45/STR49/STR50/3′MP1P, but the opposite allele at 5′(CA)nrepeat and STR07 indicated that the fetus inherited a recombinant DMD gene. c The proband (II3) had the deletion of exon 45–47. The large deletion cannot be found in the mother’s (I2) peripheral blood. The male fetus had the deletion of exon47 detected by MLPA. Linkage analysis showed that the fetus inherited the same high-risk haplotype as the affected proband at the following STR markers: STR49/STR50/3′MP1P, but the opposite allele at 5′(CA)nrepeat/STR07/STR44/STR45 indicated that the fetus inherited a recombinant DMD gene

Back to article page