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Table 3 Correlating mutation versus clinical disease severity

From: Retinoblastoma genetics screening and clinical management

  Splice site mutation Missenese mutation Termination Whole gene deletion
Total 4 7 14 4
U:B 0:04 3:04 0:14 1:03
Age (years) 1.45 1.81 1.28 4.09
Enucleation 4 (100%) 7 (100%) 10 (71.4%) 3 (75%)
Average age at enucleation (years) 1.83 1.95 2.02 1.98 *
Avg pathological TNM 2.6 2.14 1.85 2.3
Avg clinical TNM 3.3 2.7 2.38 2.75
  1. *Average age of enucleation calculated after excluding 1 patient who was enucleated at 13.77 years