Table 4 SNPs reaching borderline significance threshold

Agrawal, 2011

DSM-IV cannabis dependence

hg18

rs1019238

17

ANKFN1

EA = 0.4, AA = 0.1

3054

OR

1.453

95% CI

1.254–1.682

6.1E−07

AA & EA

rs1431318

17

ANKFN1

EA = 0.44, AA = 0.25

3054

OR

0.708

95% CI

0.616–0.812

9.14E−07

AA & EA

Agrawal, 2014

Cannabis use disorder factor scores from 12 DSM IV + 5 criteria

hg18

rs4364205

3

T

0.41

1035

β

− 0.19

95% CI

− 0.26−  (− 0.12)

1.3E−07

AA

Demontis, 2019

Cannabis use disorder

hg19

rs56372821

8

A/G

A

0.163

51,372

OR

0.728

9.31E−12

EA

rs4732724

8

C/G

C

0.324

51,372

OR

0.82

1.34E−08

EA

rs6558008

8

A/C

A

0.755

51,372

OR

1.237

2.45E−08

EA

rs73229090

8

A/C

A

0.11

51,372

OR

0.702

7.41E−10

EA

rs937220

8

A/G

A

0.259

51,372

OR

0.8258

2.46E−07

EA

Minica, 2015

Cannabis initiation

GRCh37

rs35487050

19:35,221,228

C/T

ZNF181

6744

β

0.81

SE

0.16

1.68E−07

E

rs35917943

19:35,147,183

C/A

 < 0.05

6744

β

0.77

SE

0.15

1.62E−07

E

rs35760174

19:35,221,582

C/G

6744

β

0.76

SE

0.15

7.04E−07

E

Age of onset of cannabis use

rs142324060

5:95,425,757

G/A

 < 0.05

5148

β

0.68

SE

0.11

7.66E−08

E

rs78505392

5:95,422,966

C/G

5148

β

0.58

SE

0.1

2.16E−07

E

rs12003072

9:86,771,161

A/C

5148

β

0.52

SE

0.09

3.04E−07

E

rs77097806

5:95,456,735

A/G

5148

β

0.56

SE

0.1

3.54E−07

E

rs6879646

5:95,450,187

A/G

5148

β

0.57

SE

0.1

3.61E−07

E

rs4613744

5:95,451,494

C/T

5148

β

0.55

SE

0.1

5.07E−07

E

rs60218730

5:95,492,765

G/T

5148

β

0.59

SE

0.11

5.98E−07

E

rs74305417

9:86,779,774

C/G

5148

β

0.52

SE

0.09

6.2E−07

E

rs142981069

18:58,826,022

G/A

5148

β

0.47

SE

0.09

7.25E−07

E

rs12386084

18:58,827,145

C/G

5148

β

0.47

SE

0.09

7.25E−07

E

rs117918936

18:58,828,323

G/A

5148

β

0.47

SE

0.09

7.25E−07

E

rs2160801

18:58,829,024

T/A

5148

β

0.47

SE

0.09

7.25E−07

E

rs145424173

18:58,829,597

T/C

5148

β

0.47

SE

0.09

7.25E−07

E

rs117538409

18:58,830,942

G/C

5148

β

0.47

SE

0.09

7.25E−07

E

rs17817245

18:58,832,135

A/G

5148

β

0.47

SE

0.09

7.25E−07

E

rs140206809

18:58,833,215

A/G

5148

β

0.47

SE

0.09

7.25E−07

E

rs117692712

18:58,834,506

T/G

5148

β

0.47

SE

0.09

7.25E−07

E

rs17817423

18:58,835,462

C/T

5148

β

0.47

SE

0.09

7.25E−07

E

rs9916935

18:58,835,931

T/C

5148

β

0.47

SE

0.09

7.25E−07

E

rs192013604

18:58,838,324

T/C

5148

β

0.47

SE

0.09

7.25E−07

E

rs117471640

18:58,838,402

A/G

5148

β

0.47

SE

0.09

7.25E−07

E

rs78456402

9:86,781,900

C/A

5148

β

0.5

SE

0.09

9.09E−07

E

rs11998981

9:86,783,107

T/C

5148

β

0.5

SE

0.09

9.09E−07

E

rs79236058

5:95,478,830

G/A

5148

β

0.57

SE

0.1

9.59E−07

E

Pasman, 2018

Lifetime cannabis use

hg19

rs7609594

3:85,482,595

G/A

A

CADM2

0.38

126,785

β

0.068

SE

0.01

5.86E−11

E

rs4099556

4:37,067,936

G/A

A

MIR4801

0.176

126,785

β

−0.079

SE

0.013

3.56E−09

E

rs78680891

3:51,028,954

C/G

C

0.002299

126,574

β

− 0.52473

SE

0.106473

8.30E−07

E

rs2071704

4:3,240,159

C/T

C

0.419929

125,953

β

− 0.04974

SE

0.010162

9.83E−07

E

rs76565656

7:148,048,453

G/A

G

0.122539

124,918

β

− 0.07974

SE

0.015258

1.73E−07

E

rs4308708

8:76,702,058

A/C

A

0.041699

126,193

β

− 0.13628

SE

0.025107

5.70E−08

E

rs10883796

10:104,655,315

G/A

G

0.296441

126,444

β

− 0.05638

SE

0.010951

2.62E−07

E

rs11186071

10:91,969,337

G/A

G

0.004168

126,711

β

− 0.90907

SE

0.18524

9.22E−07

E

rs11214441

11:112,846,713

T/A

T

0.394257

126,761

β

− 0.05354

SE

0.010263

1.82E−07

E

rs5442

12:6,954,864

G/A

G

0.066921

126,785

β

− 0.09622

SE

0.019181

5.27E−07

E

rs75448266

12:6,798,632

A/C

A

0.084049

125,672

β

− 0.0944

SE

0.017746

1.04E−07

E

rs17083392

13:69,026,559

A/G

A

0.004286

126,745

β

− 1.60924

SE

0.3177

4.08E−07

E

rs2019135

13:69,034,323

T/C

T

0.004267

126,772

β

− 1.76061

SE

0.323766

5.39E−08

E

rs2019150

13:69,034,188

C/A

C

0.004262

126,771

β

− 1.76061

SE

0.323766

5.39E−08

E

rs677755

13:69,041,438

T/C

T

0.00486

126,760

β

1.426

SE

0.290601

9.24E−07

E

rs74632168

13:69,048,954

C/T

C

0.004056

126,772

β

− 1.72062

SE

0.319014

6.91E−08

E

rs2650494

16:28,318,440

A/G

A

0.414312

124,286

β

− 0.05259

SE

0.010223

2.68E−07

E

rs325363

18:38,331,295

G/A

G

0.229965

126,624

β

0.059212

SE

0.011689

4.07E−07

E

rs4492854

11:112,983,534

C/T

C

0.4363

30,366

β

0.1113

SE

0.021251

1.63E−07

E

Sherva, 2016

DSM-IV cannabis dependence criteria count

GRCh37

-

1:212,183,114:I

INTS7

1250

2.05E−07

AA

rs141482228

INTS7

1250

8.84E−10

AA

rs77349458

SNORA26,INTS7

1250

1.57E−07

AA

rs77448142

RPS20P10,RPS20P10-CYP26B1

1250

2.13E−07

AA

-

2:167,239,818:D

SCN9A-SCN7A

4750

7.43E−07

AA

rs313542

PI4K2B

2640

7.12E−10

EA

rs7689780

PI4K2B,PI4K2B-ZCCHC4

2640

4.63E−07

EA

rs73323306

ARL2BPP5-RP11-541P9.3

4750

7.61E−09

AA

rs7832545

CSMD1

2640

3.61E−10

EA

3.02E−07*

rs77378271

CSMD1

2640

5.30E−10

EA

6.69E−07*

rs75721860

CSMD1

2640

2.75E−09

EA

rs7853028

PSMB7

1250

8.94E−09

AA

rs4643011

HABP2

1250

7.21E−07

AA

rs116474042

RP11-755E23.3-CCDC67

4750

3.81E−07

AA

rs189167038

SNORD11-RNU6-1014P

1250

2.64E−09

AA

rs142162415

SNORD11-RNU6-1014P

1250

1.88E−08

AA

rs117047810

SNORD11-RNU6-1014P

1250

5.68E−08

AA

rs11466037

MEFV

1250

8.08E−07

AA

rs183568578

MEFV

1250

5.62E−07

AA

rs114269992

RP5-860P4.2-CST7

1250

2.13E−07

AA

1.63E−07*

rs114620529

RP5-860P4.2-CST7

1250

2.15E−07

1.61E−07

AA

rs116629084

RP5-860P4.2-CST7

1250

1.70E−07

AA

1.27E−07*

rs115384512

RP5-860P4.2-CST7

1250

8.91E−08

AA

7.19E−08*

rs147641662

CST7,RP5-860P4.2-CST7

1250

8.87E−08

AA

7.13E−08*

rs191783144

CST7,RP5-860P4.2-CST7

1250

8.81E−08

AA

7.07E−08*

rs146806338

CST7,RP5-860P4.2-CST7

1250

8.80E−08

AA

7.03E−08*

rs114828727

CST7,APMAP,CST7-APMAP

1250

9.01E−08

AA

6.92E−08*

rs114128002

APMAP

1250

8.06E−08

AA

6.33E−08*

rs115342711

RNU6-1257P,APMAP

1250

2.54E−07

AA

1.15E−07*

-

20:24,955,422:I

RNU6-1257P,APMAP

1250

2.54E−07

AA

1.15E−07*

rs115764440

APMAP

1250

2.33E−07

AA

9.03E−08*

rs116068335

APMAP-ACSS1

1250

1.66E−07

AA

5.62E−08*

rs114637142

ACSS1,APMAP-ACSS1

1250

9.15E−08

AA

rs114071901

ACSS1

1250

1.06E−07

AA

rs113232742

ACSS1

1250

8.82E−08

AA

rs114199928

ACSS1

1250

8.42E−08

AA

rs114836364

ACSS1

1250

8.23E−08

AA

rs116669368

ACSS1

1250

5.08E−08

AA

rs145379934

ACSS1

1250

3.96E−08

AA

rs143020225

2:167,214,714

G/A

G

snoU13,SCN9A

0.95

4750

5.85E−07

AA

-

chr22:26,917,069:I

C9.15,TPST2,CTA-445C9.14-CTA-4

2640

3.15E−10

EA

rs4149485

TPST2,CTA-445C9.15

2640

2.24E−10

EA