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Table 4 SNPs reaching borderline significance threshold

From: Genetic basis of cannabis use: a systematic review

First Author Last Name, Year Outcome associated with SNP Build SNP IDs Chr:Pos Alleles Minor Allele Gene or Locus MAF N Measure of Association type Measure of Association value Measure of Variability Measure of Variability value p value Ethnicity
Agrawal, 2011 DSM-IV cannabis dependence hg18 rs1019238 17    ANKFN1 EA = 0.4, AA = 0.1 3054 OR 1.453 95% CI 1.254–1.682 6.1E07 AA & EA
rs1431318 17    ANKFN1 EA = 0.44, AA = 0.25 3054 OR 0.708 95% CI 0.616–0.812 9.14E07 AA & EA
Agrawal, 2014 Cannabis use disorder factor scores from 12 DSM IV + 5 criteria hg18 rs4364205 3   T   0.41 1035 β − 0.19 95% CI − 0.26−  (− 0.12) 1.3E07 AA
Demontis, 2019 Cannabis use disorder hg19 rs56372821 8 A/G A   0.163 51,372 OR 0.728    9.31E−12 EA
rs4732724 8 C/G C   0.324 51,372 OR 0.82    1.34E−08 EA
rs6558008 8 A/C A   0.755 51,372 OR 1.237    2.45E−08 EA
rs73229090 8 A/C A   0.11 51,372 OR 0.702    7.41E−10 EA
rs937220 8 A/G A   0.259 51,372 OR 0.8258    2.46E07 EA
Minica, 2015 Cannabis initiation GRCh37 rs35487050 19:35,221,228 C/T   ZNF181   6744 β 0.81 SE 0.16 1.68E07 E
rs35917943 19:35,147,183 C/A     < 0.05 6744 β 0.77 SE 0.15 1.62E07 E
rs35760174 19:35,221,582 C/G     6744 β 0.76 SE 0.15 7.04E07 E
Age of onset of cannabis use rs142324060 5:95,425,757 G/A     < 0.05 5148 β 0.68 SE 0.11 7.66E08 E
rs78505392 5:95,422,966 C/G     5148 β 0.58 SE 0.1 2.16E07 E
rs12003072 9:86,771,161 A/C     5148 β 0.52 SE 0.09 3.04E07 E
rs77097806 5:95,456,735 A/G     5148 β 0.56 SE 0.1 3.54E07 E
rs6879646 5:95,450,187 A/G     5148 β 0.57 SE 0.1 3.61E07 E
rs4613744 5:95,451,494 C/T     5148 β 0.55 SE 0.1 5.07E07 E
rs60218730 5:95,492,765 G/T     5148 β 0.59 SE 0.11 5.98E07 E
rs74305417 9:86,779,774 C/G     5148 β 0.52 SE 0.09 6.2E07 E
rs142981069 18:58,826,022 G/A     5148 β 0.47 SE 0.09 7.25E07 E
rs12386084 18:58,827,145 C/G     5148 β 0.47 SE 0.09 7.25E07 E
rs117918936 18:58,828,323 G/A     5148 β 0.47 SE 0.09 7.25E07 E
rs2160801 18:58,829,024 T/A     5148 β 0.47 SE 0.09 7.25E07 E
rs145424173 18:58,829,597 T/C     5148 β 0.47 SE 0.09 7.25E07 E
rs117538409 18:58,830,942 G/C     5148 β 0.47 SE 0.09 7.25E07 E
rs17817245 18:58,832,135 A/G     5148 β 0.47 SE 0.09 7.25E07 E
rs140206809 18:58,833,215 A/G     5148 β 0.47 SE 0.09 7.25E07 E
rs117692712 18:58,834,506 T/G     5148 β 0.47 SE 0.09 7.25E07 E
rs17817423 18:58,835,462 C/T     5148 β 0.47 SE 0.09 7.25E07 E
rs9916935 18:58,835,931 T/C     5148 β 0.47 SE 0.09 7.25E07 E
rs192013604 18:58,838,324 T/C     5148 β 0.47 SE 0.09 7.25E07 E
rs117471640 18:58,838,402 A/G     5148 β 0.47 SE 0.09 7.25E07 E
rs78456402 9:86,781,900 C/A     5148 β 0.5 SE 0.09 9.09E07 E
rs11998981 9:86,783,107 T/C     5148 β 0.5 SE 0.09 9.09E07 E
rs79236058 5:95,478,830 G/A     5148 β 0.57 SE 0.1 9.59E07 E
Pasman, 2018 Lifetime cannabis use hg19 rs7609594 3:85,482,595 G/A A CADM2 0.38 126,785 β 0.068 SE 0.01 5.86E−11 E
rs4099556 4:37,067,936 G/A A MIR4801 0.176 126,785 β −0.079 SE 0.013 3.56E−09 E
rs78680891 3:51,028,954 C/G C   0.002299 126,574 β − 0.52473 SE 0.106473 8.30E07 E
rs2071704 4:3,240,159 C/T C   0.419929 125,953 β − 0.04974 SE 0.010162 9.83E07 E
rs76565656 7:148,048,453 G/A G   0.122539 124,918 β − 0.07974 SE 0.015258 1.73E07 E
rs4308708 8:76,702,058 A/C A   0.041699 126,193 β − 0.13628 SE 0.025107 5.70E08 E
rs10883796 10:104,655,315 G/A G   0.296441 126,444 β − 0.05638 SE 0.010951 2.62E07 E
rs11186071 10:91,969,337 G/A G   0.004168 126,711 β − 0.90907 SE 0.18524 9.22E07 E
rs11214441 11:112,846,713 T/A T   0.394257 126,761 β − 0.05354 SE 0.010263 1.82E07 E
rs5442 12:6,954,864 G/A G   0.066921 126,785 β − 0.09622 SE 0.019181 5.27E07 E
rs75448266 12:6,798,632 A/C A   0.084049 125,672 β − 0.0944 SE 0.017746 1.04E07 E
rs17083392 13:69,026,559 A/G A   0.004286 126,745 β − 1.60924 SE 0.3177 4.08E07 E
rs2019135 13:69,034,323 T/C T   0.004267 126,772 β − 1.76061 SE 0.323766 5.39E08 E
rs2019150 13:69,034,188 C/A C   0.004262 126,771 β − 1.76061 SE 0.323766 5.39E08 E
rs677755 13:69,041,438 T/C T   0.00486 126,760 β 1.426 SE 0.290601 9.24E07 E
rs74632168 13:69,048,954 C/T C   0.004056 126,772 β − 1.72062 SE 0.319014 6.91E08 E
rs2650494 16:28,318,440 A/G A   0.414312 124,286 β − 0.05259 SE 0.010223 2.68E07 E
rs325363 18:38,331,295 G/A G   0.229965 126,624 β 0.059212 SE 0.011689 4.07E07 E
rs4492854 11:112,983,534 C/T C   0.4363 30,366 β 0.1113 SE 0.021251 1.63E07 E
Sherva, 2016 DSM-IV cannabis dependence criteria count GRCh37 - 1:212,183,114:I    INTS7   1250      2.05E07 AA
rs141482228     INTS7   1250      8.84E−10 AA
rs77349458     SNORA26,INTS7   1250      1.57E07 AA
rs77448142     RPS20P10,RPS20P10-CYP26B1   1250      2.13E07 AA
- 2:167,239,818:D    SCN9A-SCN7A   4750      7.43E07 AA
rs313542     PI4K2B   2640      7.12E−10 EA
rs7689780     PI4K2B,PI4K2B-ZCCHC4   2640      4.63E07 EA
rs73323306     ARL2BPP5-RP11-541P9.3   4750      7.61E−09 AA
rs7832545     CSMD1   2640      3.61E−10 EA
3.02E07*
rs77378271     CSMD1   2640      5.30E−10 EA
6.69E07*
rs75721860     CSMD1   2640      2.75E−09 EA
rs7853028     PSMB7   1250      8.94E−09 AA
rs4643011     HABP2   1250      7.21E07 AA
rs116474042     RP11-755E23.3-CCDC67   4750      3.81E07 AA
rs189167038     SNORD11-RNU6-1014P   1250      2.64E−09 AA
rs142162415     SNORD11-RNU6-1014P   1250      1.88E−08 AA
rs117047810     SNORD11-RNU6-1014P   1250      5.68E08 AA
rs11466037     MEFV   1250      8.08E07 AA
rs183568578     MEFV   1250      5.62E07 AA
rs114269992     RP5-860P4.2-CST7   1250      2.13E07 AA
1.63E07*
rs114620529     RP5-860P4.2-CST7   1250      2.15E07
1.61E07
AA
rs116629084     RP5-860P4.2-CST7   1250      1.70E07 AA
1.27E07*
rs115384512     RP5-860P4.2-CST7   1250      8.91E08 AA
7.19E08*
rs147641662     CST7,RP5-860P4.2-CST7   1250      8.87E08 AA
7.13E08*
rs191783144     CST7,RP5-860P4.2-CST7   1250      8.81E08 AA
7.07E08*
rs146806338     CST7,RP5-860P4.2-CST7   1250      8.80E08 AA
7.03E08*
rs114828727     CST7,APMAP,CST7-APMAP   1250      9.01E08 AA
6.92E08*
rs114128002     APMAP   1250      8.06E08 AA
6.33E08*
rs115342711     RNU6-1257P,APMAP   1250      2.54E07 AA
1.15E07*
- 20:24,955,422:I    RNU6-1257P,APMAP   1250      2.54E07 AA
1.15E07*
rs115764440     APMAP   1250      2.33E07 AA
9.03E08*
rs116068335     APMAP-ACSS1   1250      1.66E07 AA
5.62E08*
rs114637142     ACSS1,APMAP-ACSS1   1250      9.15E08 AA
rs114071901     ACSS1   1250      1.06E07 AA
rs113232742     ACSS1   1250      8.82E08 AA
rs114199928     ACSS1   1250      8.42E08 AA
rs114836364     ACSS1   1250      8.23E08 AA
rs116669368     ACSS1   1250      5.08E08 AA
rs145379934     ACSS1   1250      3.96E−08 AA
rs143020225 2:167,214,714 G/A G snoU13,SCN9A 0.95 4750      5.85E07 AA
- chr22:26,917,069:I    C9.15,TPST2,CTA-445C9.14-CTA-4   2640      3.15E−10 EA
rs4149485     TPST2,CTA-445C9.15   2640      2.24E−10 EA
  1. *Adjusted for the DSM-IV criteria counts for alcohol, cocaine, and opioid dependence
  2. AA = African American, EA = European American, E = European
  3. Bold type indicates variants for which the p value reached genome-wide significance (p ≤ 5 × 10–8)