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Table 2 Relationships of polymorphisms in PDX1 and MC4R and T2DM risk

From: PDX1 and MC4R genetic polymorphisms are associated with type 2 diabetes mellitus risk in the Chinese Han population

Gene SNP Model Genotype Without adjustment With adjustment
OR (95% CI) pa OR (95% CI) pb
PDX1 rs11619319 Codominant AA 1.00   1.00  
GG 1.09 (0.76–1.56) 0.629 1.09 (0.76–1.56) 0.629
GA 0.90 (0.68–1.20) 0.471 0.90 (0.68–1.20) 0.471
Dominant AA 1.00   1.00  
GG-GA 0.95 (0.73–1.25) 0.715 0.95 (0.73–1.25) 0.717
Recessive GA-AA 1.00   1.00  
GG 1.17 (0.85–1.59) 0.333 1.17 (0.85–1.59) 0.334
Additive 1.03 (0.86–1.23) 0.755 1.03 (0.86–1.23) 0.756
PDX1 rs2293941 Codominant GG 1.00   1.00  
AA 1.09 (0.76–1.56) 0.646 1.09 (0.76–1.56) 0.646
AG 0.89 (0.67–1.18) 0.425 0.89 (0.67–1.18) 0.426
Dominant GG 1.00   1.00  
AA-AG 0.94 (0.72–1.23) 0.666 0.94 (0.72–1.23) 0.667
Recessive AG-GG 1.00   1.00  
AA 1.17 (0.85–1.60) 0.332 1.17 (0.85–1.60) 0.333
Additive 1.02 (0.86–1.22) 0.791 1.02 (0.86–1.22) 0.792
PDX1 rs9581943 Codominant GG 1.00   1.00  
AA 0.96 (0.65–1.42) 0.844 0.96 (0.65–1.41) 0.842
AG 0.76 (0.58–0.99) 0.046 0.76 (0.58–0.99) 0.045
Dominant GG 1.00   1.00  
AA-AG 0.80 (0.63–1.04) 0.090 0.80 (0.62–1.04) 0.090
Recessive AG-GG 1.00   1.00  
AA 1.11 (0.77–1.59) 0.574 1.11 (0.77–1.59) 0.574
Additive 0.92 (0.77–1.10) 0.353 0.92 (0.77–1.10) 0.354
PDX1 rs7981781 Codominant GG 1.00   1.00  
AA 1.08 (0.75–1.54) 0.681 1.08 (0.75–1.54) 0.681
AG 0.85 (0.64–1.13) 0.263 0.85 (0.64–1.13) 0.263
Dominant GG 1.00   1.00  
AA-AG 0.91 (0.70–1.19) 0.486 0.91 (0.70–1.19) 0.487
Recessive AG-GG 1.00   1.00  
AA 1.19 (0.87–1.63) 0.289 1.19 (0.86–1.63) 0.290
Additive 1.01 (0.85–1.21) 0.898 1.01 (0.85–1.21) 0.899
MC4R rs6567160 Codominant TT 1.00   1.00  
CC 0.88 (0.53–1.47) 0.627 0.88 (0.53–1.47) 0.626
CT 1.10 (0.84–1.44) 0.475 1.10 (0.84–1.44) 0.475
Dominant TT 1.00   1.00  
CC-CT 1.06 (0.83–1.37) 0.634 1.06 (0.83–1.37) 0.635
Recessive CT-TT 1.00   1.00  
CC 0.85 (0.51–1.41) 0.527 0.85 (0.51–1.41) 0.526
Additive 1.01 (0.83–1.24) 0.899 1.01 (0.83–1.24) 0.900
MC4R rs663129 Codominant GG 1.00   1.00  
AA 0.89 (0.53–1.48) 0.646 0.89 (0.53–1.48) 0.645
AG 1.12 (0.86–1.47) 0.395 1.12 (0.86–1.47) 0.396
Dominant GG 1.00   1.00  
AA-AG 1.08 (0.84–1.39) 0.545 1.08 (0.84–1.39) 0.546
Recessive AG-GG 1.00   1.00  
AA 0.85 (0.51–1.41) 0.527 0.85 (0.51–1.41) 0.526
Additive 1.02 (0.84–1.25) 0.818 1.02 (0.84–1.25) 0.820
MC4R rs17782313 Codominant TT 1.00   1.00  
CC 0.89 (0.53–1.49) 0.664 0.89 (0.53–1.49) 0.663
CT 1.14 (0.88–1.49) 0.324 1.14 (0.88–1.49) 0.324
Dominant TT 1.00   1.00  
CC-CT 1.10 (0.85–1.42) 0.463 1.10 (0.85–1.41) 0.464
Recessive CT-TT 1.00   1.00  
CC 0.85 (0.51–1.41) 0.527 0.85 (0.51–1.41) 0.526
Additive 1.04 (0.85–1.27) 0.740 1.04 (0.85–1.27) 0.741
MC4R rs12969709 Codominant CC 1.00   1.00  
AA 0.70 (0.40–1.22) 0.203 0.70 (0.40–1.21) 0.202
AC 1.06 (0.81–1.38) 0.694 1.06 (0.81–1.38) 0.695
Dominant CC 1.00   1.00  
AA-AC 0.99 (0.77–1.28) 0.969 0.99 (0.77–1.28) 0.967
Recessive AC-CC 1.00   1.00  
AA 0.68 (0.40–1.18) 0.174 0.68 (0.40–1.18) 0.173
Additive 0.94 (0.77–1.16) 0.578 0.94 (0.77–1.16) 0.577
MC4R rs11663816 Codominant TT 1.00   1.00  
CC 0.88 (0.50–1.55) 0.659 0.88 (0.50–1.55) 0.657
CT 0.98 (0.75–1.27) 0.854 0.98 (0.75–1.27) 0.852
Dominant TT 1.00   1.00  
CC-CT 0.96 (0.75–1.24) 0.766 0.96 (0.75–1.24) 0.764
Recessive CT-TT 1.00   1.00  
CC 0.89 (0.51–1.55) 0.678 0.89 (0.51–1.55) 0.676
Additive 0.96 (0.78–1.18 0.688 0.96 (0.78–1.18) 0.686
MC4R rs12970134 Codominant GG 1.00   1.00  
AA 0.83 (0.46–1.50) 0.543 0.83 (0.46–1.50) 0.542
AG 0.97 (0.74–1.26) 0.801 0.97 (0.74–1.26) 0.800
Dominant GG 1.00   1.00  
AA-AG 0.95 (0.73–1.23) 0.683 0.95 (0.73–1.23) 0.682
Recessive AG-GG 1.00   1.00  
AA 0.84 (0.47–1.51) 0.564 0.84 (0.47–1.51) 0.564
Additive 0.94 (0.76–1.17) 0.582 0.94 (0.76–1.17) 0.581
  1. SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval
  2. pa values were calculated by logistic regression analysis with the comparison between diabetes patients and healthy controls
  3. pb values were calculated by logistic regression analysis with adjustment for age and gender
  4. Bold values indicate statistical significance (p < 0.05)