PDX1 and MC4R genetic polymorphisms are associated with type 2 diabetes mellitus risk in the Chinese Han population

Wang, Ning; Tong, Rui; Xu, Jing; Tian, Yanni; Pan, Juan; Cui, Jiaqi; Chen, Huan; Peng, Yanqi; Fei, Sijia; Yang, Shujun; Wang, Lu; Yao, Juanchuan; Cui, Wei

doi:10.1186/s12920-021-01037-3

Table 2 Relationships of polymorphisms in PDX1 and MC4R and T2DM risk

From: PDX1 and MC4R genetic polymorphisms are associated with type 2 diabetes mellitus risk in the Chinese Han population

Gene	SNP	Model	Genotype	Without adjustment		With adjustment
Gene	SNP	Model	Genotype	OR (95% CI)	p^a	OR (95% CI)	p^b
PDX1	rs11619319	Codominant	AA	1.00		1.00
			GG	1.09 (0.76–1.56)	0.629	1.09 (0.76–1.56)	0.629
			GA	0.90 (0.68–1.20)	0.471	0.90 (0.68–1.20)	0.471
		Dominant	AA	1.00		1.00
		Dominant	GG-GA	0.95 (0.73–1.25)	0.715	0.95 (0.73–1.25)	0.717
		Recessive	GA-AA	1.00		1.00
		Recessive	GG	1.17 (0.85–1.59)	0.333	1.17 (0.85–1.59)	0.334
		Additive	–	1.03 (0.86–1.23)	0.755	1.03 (0.86–1.23)	0.756
PDX1	rs2293941	Codominant	GG	1.00		1.00
			AA	1.09 (0.76–1.56)	0.646	1.09 (0.76–1.56)	0.646
			AG	0.89 (0.67–1.18)	0.425	0.89 (0.67–1.18)	0.426
		Dominant	GG	1.00		1.00
		Dominant	AA-AG	0.94 (0.72–1.23)	0.666	0.94 (0.72–1.23)	0.667
		Recessive	AG-GG	1.00		1.00
		Recessive	AA	1.17 (0.85–1.60)	0.332	1.17 (0.85–1.60)	0.333
		Additive	–	1.02 (0.86–1.22)	0.791	1.02 (0.86–1.22)	0.792
PDX1	rs9581943	Codominant	GG	1.00		1.00
			AA	0.96 (0.65–1.42)	0.844	0.96 (0.65–1.41)	0.842
			AG	0.76 (0.58–0.99)	0.046	0.76 (0.58–0.99)	0.045
		Dominant	GG	1.00		1.00
		Dominant	AA-AG	0.80 (0.63–1.04)	0.090	0.80 (0.62–1.04)	0.090
		Recessive	AG-GG	1.00		1.00
		Recessive	AA	1.11 (0.77–1.59)	0.574	1.11 (0.77–1.59)	0.574
		Additive	–	0.92 (0.77–1.10)	0.353	0.92 (0.77–1.10)	0.354
PDX1	rs7981781	Codominant	GG	1.00		1.00
			AA	1.08 (0.75–1.54)	0.681	1.08 (0.75–1.54)	0.681
			AG	0.85 (0.64–1.13)	0.263	0.85 (0.64–1.13)	0.263
		Dominant	GG	1.00		1.00
		Dominant	AA-AG	0.91 (0.70–1.19)	0.486	0.91 (0.70–1.19)	0.487
		Recessive	AG-GG	1.00		1.00
		Recessive	AA	1.19 (0.87–1.63)	0.289	1.19 (0.86–1.63)	0.290
		Additive	–	1.01 (0.85–1.21)	0.898	1.01 (0.85–1.21)	0.899
MC4R	rs6567160	Codominant	TT	1.00		1.00
			CC	0.88 (0.53–1.47)	0.627	0.88 (0.53–1.47)	0.626
			CT	1.10 (0.84–1.44)	0.475	1.10 (0.84–1.44)	0.475
		Dominant	TT	1.00		1.00
		Dominant	CC-CT	1.06 (0.83–1.37)	0.634	1.06 (0.83–1.37)	0.635
		Recessive	CT-TT	1.00		1.00
		Recessive	CC	0.85 (0.51–1.41)	0.527	0.85 (0.51–1.41)	0.526
		Additive	–	1.01 (0.83–1.24)	0.899	1.01 (0.83–1.24)	0.900
MC4R	rs663129	Codominant	GG	1.00		1.00
			AA	0.89 (0.53–1.48)	0.646	0.89 (0.53–1.48)	0.645
			AG	1.12 (0.86–1.47)	0.395	1.12 (0.86–1.47)	0.396
		Dominant	GG	1.00		1.00
		Dominant	AA-AG	1.08 (0.84–1.39)	0.545	1.08 (0.84–1.39)	0.546
		Recessive	AG-GG	1.00		1.00
		Recessive	AA	0.85 (0.51–1.41)	0.527	0.85 (0.51–1.41)	0.526
		Additive	–	1.02 (0.84–1.25)	0.818	1.02 (0.84–1.25)	0.820
MC4R	rs17782313	Codominant	TT	1.00		1.00
			CC	0.89 (0.53–1.49)	0.664	0.89 (0.53–1.49)	0.663
			CT	1.14 (0.88–1.49)	0.324	1.14 (0.88–1.49)	0.324
		Dominant	TT	1.00		1.00
		Dominant	CC-CT	1.10 (0.85–1.42)	0.463	1.10 (0.85–1.41)	0.464
		Recessive	CT-TT	1.00		1.00
		Recessive	CC	0.85 (0.51–1.41)	0.527	0.85 (0.51–1.41)	0.526
		Additive	–	1.04 (0.85–1.27)	0.740	1.04 (0.85–1.27)	0.741
MC4R	rs12969709	Codominant	CC	1.00		1.00
			AA	0.70 (0.40–1.22)	0.203	0.70 (0.40–1.21)	0.202
			AC	1.06 (0.81–1.38)	0.694	1.06 (0.81–1.38)	0.695
		Dominant	CC	1.00		1.00
		Dominant	AA-AC	0.99 (0.77–1.28)	0.969	0.99 (0.77–1.28)	0.967
		Recessive	AC-CC	1.00		1.00
		Recessive	AA	0.68 (0.40–1.18)	0.174	0.68 (0.40–1.18)	0.173
		Additive	–	0.94 (0.77–1.16)	0.578	0.94 (0.77–1.16)	0.577
MC4R	rs11663816	Codominant	TT	1.00		1.00
			CC	0.88 (0.50–1.55)	0.659	0.88 (0.50–1.55)	0.657
			CT	0.98 (0.75–1.27)	0.854	0.98 (0.75–1.27)	0.852
		Dominant	TT	1.00		1.00
		Dominant	CC-CT	0.96 (0.75–1.24)	0.766	0.96 (0.75–1.24)	0.764
		Recessive	CT-TT	1.00		1.00
		Recessive	CC	0.89 (0.51–1.55)	0.678	0.89 (0.51–1.55)	0.676
		Additive	–	0.96 (0.78–1.18	0.688	0.96 (0.78–1.18)	0.686
MC4R	rs12970134	Codominant	GG	1.00		1.00
			AA	0.83 (0.46–1.50)	0.543	0.83 (0.46–1.50)	0.542
			AG	0.97 (0.74–1.26)	0.801	0.97 (0.74–1.26)	0.800
		Dominant	GG	1.00		1.00
		Dominant	AA-AG	0.95 (0.73–1.23)	0.683	0.95 (0.73–1.23)	0.682
		Recessive	AG-GG	1.00		1.00
		Recessive	AA	0.84 (0.47–1.51)	0.564	0.84 (0.47–1.51)	0.564
		Additive	–	0.94 (0.76–1.17)	0.582	0.94 (0.76–1.17)	0.581

SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval
p^a values were calculated by logistic regression analysis with the comparison between diabetes patients and healthy controls
p^b values were calculated by logistic regression analysis with adjustment for age and gender
Bold values indicate statistical significance (p < 0.05)

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