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Table 6 Haplotype analysis of PDX1 and MC4R SNPs with T2DM risk

From: PDX1 and MC4R genetic polymorphisms are associated with type 2 diabetes mellitus risk in the Chinese Han population

Gene SNP Haplotype Frequency in cases Frequency in controls With adjustment Without adjustment
OR (95%CI) p OR (95%CI) p
PDX1 rs11619319|rs2293941 GA 0.446 0.440 1.02 (0.86–1.22) 0.791 1.02 (0.86–1.22) 0.792
PDX1 rs11619319|rs2293941 AG 0.451 0.444 1.03 (0.86–1.23) 0.755 1.03 (0.86–1.23) 0.756
PDX1 rs9581943|rs7981781 GA 0.432 0.431 1.00 (0.84–1.20) 0.969 1.00 (0.84–1.20) 0.970
PDX1 rs9581943|rs7981781 AG 0.350 0.372 0.91 (0.72–1.09) 0.307 0.91 (0.76–1.09) 0.308
PDX1 rs9581943|rs7981781 GG 0.216 0.197 1.13 (0.91–1.40) 0.283 1.13 (0.91–1.40) 0.284
MC4R rs6567160|rs663129|rs17782313 CAC 0.237 0.233 1.02 (0.84–1.25) 0.819 1.02 (0.84–1.25) 0.820
MC4R rs6567160|rs663129|rs17782313 TGT 0.239 0.235 1.02 (0.84–1.25) 0.818 1.02 (0.84–1.25) 0.819
MC4R rs11663816|rs12970134 CA 0.204 0.217 0.93 (0.75–1.15) 0.510 0.93 (0.75–1.15) 0.509
MC4R rs11663816|rs12970134 CG 0.015 0.011 1.38 (0.63–3.04) 0.423 1.38 (0.63–3.04) 0.423
MC4R rs11663816|rs12970134 TG 0.221 0.228 0.97 (0.78–1.19) 0.746 0.97 (0.78–1.19) 0.744
  1. SNP single nucleotide polymorphism, OR odd ratios, CI confidence interval