PDX1 and MC4R genetic polymorphisms are associated with type 2 diabetes mellitus risk in the Chinese Han population

Table 6 Haplotype analysis of PDX1 and MC4R SNPs with T2DM risk

Gene	SNP	Haplotype	Frequency in cases	Frequency in controls	With adjustment		Without adjustment
Gene	SNP	Haplotype	Frequency in cases	Frequency in controls	OR (95%CI)	p	OR (95%CI)	p
PDX1	rs11619319\|rs2293941	GA	0.446	0.440	1.02 (0.86–1.22)	0.791	1.02 (0.86–1.22)	0.792
PDX1	rs11619319\|rs2293941	AG	0.451	0.444	1.03 (0.86–1.23)	0.755	1.03 (0.86–1.23)	0.756
PDX1	rs9581943\|rs7981781	GA	0.432	0.431	1.00 (0.84–1.20)	0.969	1.00 (0.84–1.20)	0.970
PDX1	rs9581943\|rs7981781	AG	0.350	0.372	0.91 (0.72–1.09)	0.307	0.91 (0.76–1.09)	0.308
PDX1	rs9581943\|rs7981781	GG	0.216	0.197	1.13 (0.91–1.40)	0.283	1.13 (0.91–1.40)	0.284
MC4R	rs6567160\|rs663129\|rs17782313	CAC	0.237	0.233	1.02 (0.84–1.25)	0.819	1.02 (0.84–1.25)	0.820
MC4R	rs6567160\|rs663129\|rs17782313	TGT	0.239	0.235	1.02 (0.84–1.25)	0.818	1.02 (0.84–1.25)	0.819
MC4R	rs11663816\|rs12970134	CA	0.204	0.217	0.93 (0.75–1.15)	0.510	0.93 (0.75–1.15)	0.509
MC4R	rs11663816\|rs12970134	CG	0.015	0.011	1.38 (0.63–3.04)	0.423	1.38 (0.63–3.04)	0.423
MC4R	rs11663816\|rs12970134	TG	0.221	0.228	0.97 (0.78–1.19)	0.746	0.97 (0.78–1.19)	0.744

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