Fig. 6
From: Deletion of 2 amino acids in IHH in a Japanese family with brachydactyly type A1
a, b Three-dimensional structure modelling of the N-terminal active fragment of the Indian Hedgehog protein using PyMOL. a shows the semitransparent molecular surface over a ribbon diagram of IHH-N (left) bound to CDO (right). The model shows that Ser182 and Lys183 are located on the same surface as other residues associated with BDA1. BDA1-associated residues are represented in red. b shows the IHH-N-CDO interface in the same orientation as in a. Ser182 and Lys183 on IHH-N interact with Glu922 and Glu897 on CDO respectively, via hydrogen bonds. Hydrogen bonds are depicted as dotted lines