Table 1 The prognostic value of MSI/LOH status of loci in tumor-related genes and B5
Loci | Total (n = 256) | II (n = 127) | III (n = 93) | Chemotherapy (n = 132) | ||||
|---|---|---|---|---|---|---|---|---|
OS | PFS | OS | PFS | OS | PFS | OS | PFS | |
D17S250 | MSI p = 0.001 | MSI p = 0.02 | MSI p = 0.006 | – | MSI p = 0.002 | MSI p = 0.01 | MSI p = 0.023 | – |
MSH2-15 | MSI p = 0.001 | MSI p = 0.006 | MSI p = 0.001 | MSI p = 0.001 | – | – | – | – |
pinch-5 | MSI p = 0.03 | – | MSI p = 0.001 | MSI p = 0.001 | – | – | – | – |
MCC-25 | – | MSI p = 0.048 | MSI p = 0.024 | MSI p = 0.01 | – | – | – | – |
MCC-10 | MSI p = 0.001 | MSI p = 0.001 | MSI p = 0.001 | MSI p = 0.001 | MSI p = 0.003 | MSI p = 0.001 | MSI p = 0.001 | MSI p = 0.001 |
MCC-3 | – | – | MSI p = 0.036 | – | – | – | – | – |
MCC-26 | – | – | MSI p = 0.049 | – | – | – | – | – |
MGMT-10 | – | – | MSI p = 0.04 | MSI p = 0.02 | – | – | – | – |
APC-6 | – | – | MSI p = 0.049 | – | – | – | – | – |
BRAF-9 | – | – | – | MSI p = 0.019 | – | LOH p = 0.001 | – | – |
P21 | – | – | – | – | LOH p = 0.009 | LOH p = 0.021 | – | – |
MLH1-2 | – | – | – | – | LOH p = 0.006 | LOH p = 0.004 | – | – |
Pinch-13 | – | – | – | – | – | LOH p = 0.035 | – | – |
BAT25 | – | – | – | – | – | – | LOH p = 0.048 | – |