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Table 1 The prognostic value of MSI/LOH status of loci in tumor-related genes and B5

From: Characterization and clinical evaluation of microsatellite instability and loss of heterozygosity within tumor-related genes in colorectal cancer

Loci Total (n = 256) II (n = 127) III (n = 93) Chemotherapy (n = 132)
OS PFS OS PFS OS PFS OS PFS
D17S250 MSI p = 0.001 MSI p = 0.02 MSI p = 0.006 MSI p = 0.002 MSI p = 0.01 MSI p = 0.023
MSH2-15 MSI p = 0.001 MSI p = 0.006 MSI p = 0.001 MSI p = 0.001
pinch-5 MSI p = 0.03 MSI p = 0.001 MSI p = 0.001
MCC-25 MSI p = 0.048 MSI p = 0.024 MSI p = 0.01
MCC-10 MSI p = 0.001 MSI p = 0.001 MSI p = 0.001 MSI p = 0.001 MSI p = 0.003 MSI p = 0.001 MSI p = 0.001 MSI p = 0.001
MCC-3 MSI p = 0.036
MCC-26 MSI p = 0.049
MGMT-10 MSI p = 0.04 MSI p = 0.02
APC-6 MSI p = 0.049
BRAF-9 MSI p = 0.019 LOH p = 0.001
P21 LOH p = 0.009 LOH p = 0.021
MLH1-2 LOH p = 0.006 LOH p = 0.004
Pinch-13 LOH p = 0.035
BAT25 LOH p = 0.048
  1. Total, all of the patients; II, stage II patients; III, stage III patients; Chemotherapy, patients received adjuvant chemotherapy; OS, 5-year overall survival; PFS, 5-year progression free survival. MSI, MSI status of the loci is related to OS or PFS; LOH, LOH status of the loci is related to OS or PFS. p values were obtained from log-rank test