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Table 2 The cox regression survival analysis in the entire group of patients (n = 256)

From: Characterization and clinical evaluation of microsatellite instability and loss of heterozygosity within tumor-related genes in colorectal cancer

Factors OS (n = 256) PFS (n = 256)
HR (95%CI) p value HR (95%CI) p value
Gender 2.010 (0.875–4.616) 1.000 1.881 (0.816–4.334) 0.138
Smoking 3.975 (1.565–10.079) 0.004 4.205 (1.645–10.752) 0.003
Drinking 0.281 (0.090–0.885) 0.030 0.299 (0.095–0.943) 0.039
TNM Stage 0.246 (0.102–0.595) 0.002 0.253 (0.105–0.607) 0.002
Depth of tumor invasion 0.623 (0.077–5.076) 0.659 0.600 (0.073–4.900) 0.634
Lymph node involvement a a a a
Presence of metastasis a a a a
Pathological type 0.960 (0.327–2.818) 0.940 0.905 (0.306–2.675) 0.857
Chemotherapy 0.240 (0.106–0.547) 0.001 0.215 (0.092–0.502)  < 0.001
D17S250 (MSI) 1.494 (0.448–4.983) 0.514 1.248 (0.372–4.186) 0.719
MSH2-15 (MSI) 7.701 (1.039–57.030) 0.043 11.240 (1.992–63.410) 0.006
pinch-5 (MSI) 0.426 (0.023–7.987) 0.569
MCC-25 (MSI) 0.056 (0.002–1.628) 0.094
MCC-10 (MSI) 8.845 (0.610–128.268) 0.110 31.851 (2.546–398.477) 0.007
  1. The symbol (bold) represent the difference is statistically significant
  2. a, degree of freedom was reduced because of constant or linearly dependent covariates. HR and p values were obtained from cox regression survival analysis