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Fig. 4 | BMC Medical Genomics

Fig. 4

From: Detecting copy number variation in next generation sequencing data from diagnostic gene panels

Fig. 4

Creating static pools from normal samples. In step 1 normal samples are selected from available NGS runs and get listed in order of increasing coverage depth. In step 2 the coverage depth is calculated for each window across each sample. In step 3 the list of selected normal samples is divided into different pools of size K, where Pool-1 consists of the first K samples, followed by the next pool consisting of the next K samples after skipping the first sample of the previous pool. In step 4 the mean TRSW of each pool is calculated

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