Fig. 4
From: Multiple malignant tumors in a patient with familial chordoma, a case report
The sarcoma shows very high cellularity with a sheet-like growth pattern, multinucleated giant cells and necrosis (A). On higher magnification, there are high-grade pleomorphic tumor cells and multiple mitotic figures (B) with areas of heterologous osteosarcomatous differentiation (C, right). Chemotherapy effect, characterized by cell death and hyalinization, was present in ~ 60% of the tumor (D, right). Microscopy was performed as in Fig. 2