The effect of CYP7B1 polymorphisms on the risk of coronary heart disease in Hainan Han population

BMC Medical Genomics

Table 4 Association between CYP7B1 polymorphisms and CHD risk stratified by age

SNP ID	Model	Genotype	Case	Control	OR (95% CI)	p	Case	Control	OR (95% CI)	p
SNP ID	Model	Genotype	> 60 years				≤ 60 years
rs7836768	Allele	A	326	342	1		269	274	1
		G	238	226	1.11 (0.87–1.40)	0.410	181	178	1.04 (0.79–1.35)	0.796
	Codominant	AG	140	156	0.91 (0.89–1.32)	0.624	99	106	0.92 (0.61–1.39)	0.693
		GG	49	35	1.52 (0.89–2.58)	0.123	41	36	1.13 (0.66–1.93)	0.669
		AA	93	93	1		85	84	1
	Dominant	AG-GG	189	191	1.02 (0.71–1.45)	0.920	140	142	0.97 (0.66–1.43)	0.890
	Recessive	AA-AG	233	249	1		184	190	1
		GG	49	35	1.61 (1.00–2.59)	0.052	41	36	1.18 (0.72–1.93)	0.519
	Log-additive	–	–	–	1.15 (0.90–1.48)	0.266	–	–	1.03 (0.80–1.34)	0.806
rs6472155	Allele	A	388	431	1		337	320	1
		G	176	137	1.43 (1.10–1.86)	0.008	115	132	0.83 (0.62–1.11)	0.205
	Codominant	AG	124	111	1.31 (0.92–1.86)	0.130	95	104	0.82 (0.56–1.19)	0.293
		GG	26	13	2.20 (1.07–4.49)	0.031	10	14	0.64 (0.27–1.50)	0.300
		AA	132	160	1		121	108	1
	Dominant	AG-GG	150	124	1.40 (1.00–1.95)	0.048	105	118	0.79 (0.55–1.15)	0.222
	Recessive	AA-AG	256	271	1		216	212	1
		GG	26	13	1.94 (0.97–3.90)	0.062	10	14	0.70 (0.30–1.61)	0.403
	Log-additive	–	–	–	1.39 (1.06–1.83)	0.018	–	–	0.81 (0.59–1.10)	0.180
rs2980003	Allele	C	350	369	1		303	297	1
		T	214	197	1.15 (0.90–1.46)	0.273	149	155	0.94 (0.72–1.24)	0.673
	Codominant	TC	126	137	0.97 (0.68–1.39)	0.856	107	93	1.20 (0.81–1.77)	0.368
		TT	44	30	1.52 (0.89–2.61)	0.126	21	31	0.70 (0.38–1.31)	0.268
		CC	112	116	1		98	102	1
	Dominant	TC-TT	170	167	1.07 (0.76–1.50)	0.708	128	124	1.08 (0.74–1.56)	0.705
	Recessive	CC-TC	238	253	1		205	195	1
		TT	44	30	1.55 (0.94–2.57)	0.087	21	31	0.64 (0.36–1.16)	0.142
	Log-additive	–	–	–	1.15 (0.90–1.48)	0.261	–	–	0.94 (0.72–1.24)	0.574

ISSN: 1755-8794