The effect of CYP7B1 polymorphisms on the risk of coronary heart disease in Hainan Han population

BMC Medical Genomics

Table 5 Association between CYP7B1 polymorphisms and CHD risk stratified by gender

SNP ID	Model	Genotype	Case	Control	OR (95% CI)	p	Case	Control	OR (95% CI)	p
SNP ID	Model	Genotype	Women				Men
rs7836768	Allele	A	205	223	1		390	393	1
		G	141	125	1.23 (0.90–1.67)	0.191	278	279	1.00 (0.81–1.25)	0.971
	Codominant	AG	89	95	1.00 (0.63–1.59)	0.989	150	167	/	/
		GG	26	15	1.87 (0.90–3.89)	0.096	64	56	1.08 (0.69–1.68)	0.734
		AA	58	64	1		120	113	1
	Dominant	AG-GG	115	110	1.12 (0.72–1.75)	0.616	214	223	0.90 (0.66–1.24)	0.537
	Recessive	AA-AG	147	159	1		270	280	1
		GG	26	15	1.86 (0.94–3.67)	0.073	64	56	1.19 (0.80–1.77)	0.392
	Log-additive	–	–	–	1.24 (0.89–1.73)	0.201	–	–	1.01 (0.81–1.25)	0.961
rs6472155	Allele	A	239	266	1		486	485	1
		G	109	82	1.48 (1.06–2.07)	0.022	182	187	0.97 (0.76–1.23)	0.812
	Codominant	AG	73	70	1.21 (0.78–1.89)	0.393	146	145	/	/
		GG	18	6	3.17 (1.19–8.44)	0.021	18	21	1.37 (0.83–2.26)	0.652
		AA	83	98	1		170	170	1
	Dominant	AG-GG	91	76	1.37 (0.89–2.10)	0.148	164	166	0.99 (0.73–1.34)	0.937
	Recessive	AA-AG	156	168	1		316	315	1
		GG	18	6	2.91 (1.12–7.58)	0.029	18	21	0.86 (0.45–1.64)	0.637
	Log-additive	–	–	–	1.45 (1.02–2.06)	0.037	–	–	0.97 (0.75–1.25)	0.803
rs2980003	Allele	C	225	215	1		428	451	1
		T	123	133	0.88 (0.65–1.20)	0.432	240	219	1.16 (0.92–1.45)	0.212
	Codominant	TC	81	81	0.92 (0.58–1.46)	0.732	152	149	/	/
		TT	21	26	0.73 (0.37–1.43)	0.362	44	35	1.37 (0.83–2.26)	0.220
		CC	72	67	1		138	151	1
	Dominant	TC-TT	102	107	0.88 (0.57–1.35)	0.551	196	184	1.16 (0.86–1.58)	0.334
	Recessive	CC-TC	153	148	1		290	300	1
		TT	21	26	0.76 (0.41–1.43)	0.398	44	35	1.29 (0.81–2.08)	0.286
	Log-additive	–	–	–	0.87 (0.64–1.19)	0.394	–	–	1.15 (0.92–1.45)	0.220

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